NDLI: Variant antigens and endothelial receptor adhesion in Plasmodium falciparum.

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Variant antigens and endothelial receptor adhesion in Plasmodium falciparum.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Pinches, R. A. Roberts, D. J. Gardner, J. P. Newbold, C. I.
Description	Author Affiliation: Gardner JP ( Molecular Parasitology Group, Institue of Molecular Medicine, John Radcliffe Hospital, Oxford, England.);
Abstract	Parasite-derived proteins expressed on the surface of erythrocytes infected with Plasmodium falciparum are important virulence factors, since they mediate binding of infected cells to diverse receptors on vascular endothelium and are targets of a protective immune response. They are difficult to study because they undergo rapid clonal antigenic variation in vitro, which precludes the derivation of phenotypically homogeneous cultures. Here we have utilized sequence-specific proteases to dissect the role of defined antigenic variants in binding to particular receptors. By selection of protease-resistant subpopulations of parasites on defined receptors we (i) confirm the high rate of antigenic variation in vitro; (ii) demonstrate that a single infected erythrocyte can bind to intercellular adhesion molecule 1, CD36, and thrombospondin; (iii) show that binding to intercellular adhesion molecule 1 and CD36 are functions of the variant antigen; and (iv) suggest that binding to thrombospondin may be mediated by other components of the infected erythrocyte surface.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	8
Volume Number	93
Language	English
Publisher	National Academy of Sciences
Publisher Date	1996-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigens, Protozoan Genetics Endothelium, Vascular Parasitology Plasmodium Falciparum Immunology Pathogenicity Animals Antigenic Variation Antigens, CD36 Metabolism Cell Adhesion Drug Effects Endopeptidases Pharmacology Erythrocyte Aggregation Erythrocytes In Vitro Techniques Intercellular Adhesion Molecule-1 Malaria, Falciparum Membrane Glycoproteins Models, Biological Phenotype Thrombospondins Virulence Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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