NDLI: A mouse CD8 T cell-mediated acute autoimmune diabetes independent of the perforin and Fas cytotoxic pathways: possible role of membrane TNF.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 2000 Volume: 97 Issue: 26

Year: 2000 Volume: 97 Issue: 25

Year: 2000 Volume: 97 Issue: 24

Year: 2000 Volume: 97 Issue: 23

Year: 2000 Volume: 97 Issue: 22

Year: 2000 Volume: 97 Issue: 21

Year: 2000 Volume: 97 Issue: 20

Year: 2000 Volume: 97 Issue: 19

Year: 2000 Volume: 97 Issue: 18

Year: 2000 Volume: 97 Issue: 17

Year: 2000 Volume: 97 Issue: 16

Year: 2000 Volume: 97 Issue: 15

Year: 2000 Volume: 97 Issue: 14

Year: 2000 Volume: 97 Issue: 13

Year: 2000 Volume: 97 Issue: 12

Year: 2000 Volume: 97 Issue: 11

Year: 2000 Volume: 97 Issue: 10

Year: 2000 Volume: 97 Issue: 9

Year: 2000 Volume: 97 Issue: 8

Year: 2000 Volume: 97 Issue: 7

Year: 2000 Volume: 97 Issue: 6

Year: 2000 Volume: 97 Issue: 5

Year: 2000 Volume: 97 Issue: 4

Year: 2000 Volume: 97 Issue: 3

Year: 2000 Volume: 97 Issue: 2

Year: 2000 Volume: 97 Issue: 1

Power to the people: PubMed Central.

Predicting the range of linkage disequilibrium.

Connections between the processing and nuclear export of mRNA: evidence for an export license?

Manipulating the genetic identity and biochemical surface properties of individual cells with electric-field-induced fusion.

Specific molecular recognition of mixed nucleic acid sequences: an aromatic dication that binds in the DNA minor groove as a dimer.

Denaturant-induced movement of the transition state of protein folding revealed by high-pressure stopped-flow measurements.

Effects of unique ion chemistry on thin-film growth by plasma–surface interactions

The theory of everything.

The middle way.

Exercise-induced changes in expression and activity of proteins involved in insulin signal transduction in skeletal muscle: differential effects on insulin-receptor substrates 1 and 2.

Transglutaminase-catalyzed crosslinking of the Aalpha and gamma constituent chains in fibrinogen.

Structural interactions of fibroblast growth factor receptor with its ligands.

Signal recognition particle components in the nucleolus.

Competition between a sterol biosynthetic enzyme and tRNA modification in addition to changes in the protein synthesis machinery causes altered nonsense suppression.

Inactive conformation of the serpin alpha(1)-antichymotrypsin indicates two-stage insertion of the reactive loop: implications for inhibitory function and conformational disease.

Three-dimensional structure of poliovirus receptor bound to poliovirus.

Interaction of the poliovirus receptor with poliovirus.

The crystal structure of modified bovine fibrinogen.

IFN consensus sequence binding protein potentiates STAT1-dependent activation of IFNgamma-responsive promoters in macrophages.

Substitutions in the aspartate transcarbamoylase domain of hamster CAD disrupt oligomeric structure.

Clustered DNA damages induced in isolated DNA and in human cells by low doses of ionizing radiation.

PTGF-beta, a type beta transforming growth factor (TGF-beta) superfamily member, is a p53 target gene that inhibits tumor cell growth via TGF-beta signaling pathway.

Role of adenine functional groups in the recognition of the 3′-splice-site AG during the second step of pre-mRNA splicing

Yeast flavin-containing monooxygenase is induced by the unfolded protein response.

Pulling a single chromatin fiber reveals the forces that maintain its higher-order structure.

Staphylococcal protein A: Unfolding pathways, unfolded states, and differences between the B and E domains

Solid-state synthesis and mechanical unfolding of polymers of T4 lysozyme.

NMR solution structure of the human prion protein.

Fluorescence correlation spectroscopy reveals fast optical excitation-driven intramolecular dynamics of yellow fluorescent proteins.

Kinetic equilibrium of forces and molecular events in muscle contraction.

Differential quantal release of histamine and 5-hydroxytryptamine from mast cells of vesicular monoamine transporter 2 knockout mice.

Involvement of protein kinase A in fibroblast growth factor-2-activated transcription.

Coculturing diverse clonal populations prevents the early-stage neoplastic progression that occurs in the separate clones.

Analysis of receptor signaling pathways by mass spectrometry: Identification of Vav-2 as a substrate of the epidermal and platelet-derived growth factor receptors

Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway.

Overexpression of Xenopus laevis growth hormone stimulates growth of tadpoles and frogs.

Prolactin is not a juvenile hormone in Xenopus laevis metamorphosis.

Chloroplast protein and centrosomal genes, a tRNA intron, and odd telomeres in an unusually compact eukaryotic genome, the cryptomonad nucleomorph.

Molecular cytogenetic dissection of human chromosomes 3 and 21 evolution.

Molecular heterochrony in the early development of Drosophila.

Mutations in a NIMA-related kinase gene, Nek1, cause pleiotropic effects including a progressive polycystic kidney disease in mice.

Quantifying single gene copy number by measuring fluorescent probe lengths on combed genomic DNA.

Diverse karyotypic abnormalities of the c-myc locus associated with c-myc dysregulation and tumor progression in multiple myeloma.

Phosphorylation of the Neurospora clock protein FREQUENCY determines its degradation rate and strongly influences the period length of the circadian clock.

Guanidine hydrochloride blocks a critical step in the propagation of the prion-like determinant [PSI(+)] of Saccharomyces cerevisiae.

Repetitive-DNA elements are similarly distributed on Caenorhabditis elegans autosomes.

Analysis of microsatellite mutations in the mitochondrial DNA of Saccharomyces cerevisiae.

Circadian rhythms in Neurospora crassa: lipid deficiencies restore robust rhythmicity to null frequency and white-collar mutants.

Knowledge-based analysis of microarray gene expression data by using support vector machines.

A human model for multigenic inheritance: phenotypic expression in Hirschsprung disease requires both the RET gene and a new 9q31 locus.

Diversity, functionality, and stability of the T cell repertoire derived in vivo from a single human T cell precursor.

A mouse CD8 T cell-mediated acute autoimmune diabetes independent of the perforin and Fas cytotoxic pathways: possible role of membrane TNF.

Induction of resistance to diabetes in non-obese diabetic mice by targeting CD44 with a specific monoclonal antibody.

Use of soluble peptide-DR4 tetramers to detect synovial T cells specific for cartilage antigens in patients with rheumatoid arthritis.

Prophylactic DNA vaccine for hepatitis C virus (HCV) infection: HCV-specific cytotoxic T lymphocyte induction and protection from HCV-recombinant vaccinia infection in an HLA-A2.1 transgenic mouse model.

Chromosomal instability and cytoskeletal defects in oral cancer cells.

The IgG Fc receptor, FcgammaRIIB, is a target for deregulation by chromosomal translocation in malignant lymphoma.

Signal transducer and activator of transcription 3 in the heart transduces not only a hypertrophic signal but a protective signal against doxorubicin-induced cardiomyopathy.

The oncogenic LIM-only transcription factor Lmo2 regulates angiogenesis but not vasculogenesis in mice.

Pronounced and sustained central hypernoradrenergic function in major depression with melancholic features: relation to hypercortisolism and corticotropin-releasing hormone.

Potent antimalarial activity of clotrimazole in in vitro cultures of Plasmodium falciparum.

Estrogen receptors alpha and beta in the rodent mammary gland.

The long cytoplasmic tail of gp41 is required in a cell type-dependent manner for HIV-1 envelope glycoprotein incorporation into virions.

Generation of longer cDNA fragments from serial analysis of gene expression tags for gene identification.

Highly efficient electro-gene therapy of solid tumor by using an expression plasmid for the herpes simplex virus thymidine kinase gene.

A platelet-endothelium interaction mediated by lectin-like oxidized low-density lipoprotein receptor-1.

Infusion of alpha-galactosidase A reduces tissue globotriaosylceramide storage in patients with Fabry disease.

Percutaneous peptide immunization via corneum barrier-disrupted murine skin for experimental tumor immunoprophylaxis.

Molecular mechanism for silencing virally transduced genes involves histone deacetylation and chromatin condensation.

Luteinizing hormone induction of ovarian tumors: oligogenic differences between mouse strains dictates tumor disposition.

Increased expression of preprotachykinin-I and neurokinin receptors in human breast cancer cells: implications for bone marrow metastasis.

The Nef protein of HIV-1 associates with rafts and primes T cells for activation.

Melan-A/MART-1(51-73) represents an immunogenic HLA-DR4-restricted epitope recognized by melanoma-reactive CD4(+) T cells.

The role of phosphoglycans in Leishmania-sand fly interactions.

Identification of bdm-1, a gene involved in G protein beta-subunit function and alpha-subunit accumulation.

Treatment of Mycobacterium tuberculosis with antisense oligonucleotides to glutamine synthetase mRNA inhibits glutamine synthetase activity, formation of the poly-L-glutamate/glutamine cell wall structure, and bacterial replication.

A host-specific function is required for ligation of a wide variety of ribozyme-processed RNAs.

Epstein-Barr virus nuclear protein 2 interacts with p300, CBP, and PCAF histone acetyltransferases in activation of the LMP1 promoter.

Requirement for nitric oxide activation of p21(ras)/extracellular regulated kinase in neuronal ischemic preconditioning.

Adenoviral and adeno-associated viral transfer of genes to the peripheral nervous system.

Reactive oxygen species and nitric oxide mediate plasticity of neuronal calcium signaling

Effects of salicylates and aminoglycosides on spontaneous otoacoustic emissions in the Tokay gecko.

A common muscarinic pathway for diapause recovery in the distantly related nematode species Caenorhabditis elegans and Ancylostoma caninum.

Epistatic and independent functions of caspase-3 and Bcl-X(L) in developmental programmed cell death.

Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase

Role of metallothionein in nitric oxide signaling as revealed by a green fluorescent fusion protein

Corticotropin-releasing hormone causes antidiuresis and antinatriuresis by stimulating vasopressin and inhibiting atrial natriuretic peptide release in male rats.

Cloning of the Arabidopsis RTM1 gene, which controls restriction of long-distance movement of tobacco etch virus.

Nucleotide binding and autophosphorylation of the clock protein KaiC as a circadian timing process of cyanobacteria.

Explaining the moon illusion.

Prefrontal cortex and episodic memory retrieval mode.

Contribution of S opponent cells to color appearance.

Statistical methods for characterizing similarities and differences between semantic structures.

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

A mouse CD8 T cell-mediated acute autoimmune diabetes independent of the perforin and Fas cytotoxic pathways: possible role of membrane TNF.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Herrera, P. L. Harlan, D. M. Vassalli, P.
Description	Author Affiliation: Herrera PL ( Department of Morphology, University of Geneva Medical School, 1 rue Michel-Servet, 1211 Geneva 4, Switzerland. Pedro.Herrera@medecine.unige.ch);
Abstract	Double transgenic mice [rat insulin promoter (RIP)-tumor necrosis factor (TNF) and RIP-CD80] whose pancreatic beta cells release TNF and bear CD80 all develop an acute early (6 wk) and lethal diabetes mediated by CD8 T cells. The first ultrastructural changes observed in beta cells, so far unreported, are focal lesions of endoplasmic reticulum swelling at the points of contact with islet-infiltrating lymphoblasts, followed by cytoplasmic, but not nuclear, apoptosis. Such double transgenic mice were made defective in either the perforin, Fas, or TNF pathways. Remarkably, diabetes was found to be totally independent of perforin and Fas. Mice lacking TNF receptor (TNFR) II had no or late diabetes, but only a minority had severe insulitis. Mice lacking the TNF-lymphotoxin (LTalpha) locus (whose sole source of TNF are the beta cells) all had insulitis comparable to that of nondefective mice, but no diabetes or a retarded and milder form, with lesions suggesting different mechanisms of injury. Because both TNFR II and TNF-LTalpha mutations have complex effects on the immune system, these data do not formally incriminate membrane TNF as the major T cell mediator of this acute autoimmune diabetes; nevertheless, in the absence of involvement of the perforin or Fas cytotoxic pathways, membrane TNF appears to be the likeliest candidate.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	1
Volume Number	97
Language	English
Publisher	National Academy of Sciences
Publisher Date	2000-02-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigens, CD95 Genetics Autoimmunity Immunology CD8-Positive T-Lymphocytes Diabetes Mellitus Membrane Glycoproteins Tumor Necrosis Factor-alpha Animals Antigens, CD Metabolism Antigens, CD80 Apoptosis Disease Models, Animal Fluorescent Antibody Technique Insulin Islets Of Langerhans Pathology Mice Mice, Knockout Mice, Transgenic Microscopy, Electron Pancreas Perforin Pore Forming Cytotoxic Proteins Promoter Regions, Genetic Receptors, Tumor Necrosis Factor Receptors, Tumor Necrosis Factor, Type II Signal Transduction Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in