NDLI: A common muscarinic pathway for diapause recovery in the distantly related nematode species Caenorhabditis elegans and Ancylostoma caninum.

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A common muscarinic pathway for diapause recovery in the distantly related nematode species Caenorhabditis elegans and Ancylostoma caninum.

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A common muscarinic pathway for diapause recovery in the distantly related nematode species Caenorhabditis elegans and Ancylostoma caninum.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hawdon, J. Ruvkun, G. Perregaux, M. Tissenbaum, H. A. Hotez, P. Guarente, L.
Description	Author Affiliation: Tissenbaum HA ( Department of Biology, Massachusetts Institute of Technology, Building 68-289, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.);
Abstract	Converging TGF-beta and insulin-like neuroendocrine signaling pathways regulate whether Caenorhabditis elegans develops reproductively or arrests at the dauer larval stage. We examined whether neurotransmitters act in the dauer entry or recovery pathways. Muscarinic agonists promote recovery from dauer arrest induced by pheromone as well as by mutations in the TGF-beta pathway. Dauer recovery in these animals is inhibited by the muscarinic antagonist atropine. Muscarinic agonists do not induce dauer recovery of either daf-2 or age-1 mutant animals, which have defects in the insulin-like signaling pathway. These data suggest that a metabotropic acetylcholine signaling pathway activates an insulin-like signal during C. elegans dauer recovery. Analogous and perhaps homologous cholinergic regulation of mammalian insulin release by the autonomic nervous system has been noted. In the parasitic nematode Ancylostoma caninum, the dauer larval stage is the infective stage, and recovery to the reproductive stage normally is induced by host factors. Muscarinic agonists also induce and atropine potently inhibits in vitro recovery of A. caninum dauer arrest. We suggest that host or parasite insulin-like signals may regulate recovery of A. caninum and could be potential targets for antihelminthic drugs.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	1
Volume Number	97
Language	English
Publisher	National Academy of Sciences
Publisher Date	2000-02-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Ancylostoma Metabolism Caenorhabditis Elegans Larva Muscarinic Agonists Pharmacology Muscarinic Antagonists Signal Transduction Ancylostomatoidea Animals Arecoline Atropine Insulin Neuropeptides Neurotransmitter Agents Agonists Antagonists & Inhibitors Oxotremorine Pilocarpine Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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