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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Nagarkatti, Nisha Strominger, Jack L. Boyson, Jonathan E. Exley, Mark A. Nizam, Leena |
| Description | Author Affiliation: Boyson JE ( Division of Transplantation Surgery and Immunology, Department of Surgery, University of Vermont College of Medicine, Burlington, VT 05405, USA.); |
| Abstract | Stimulation of CD1d-restricted semiinvariant natural killer T cells by using the CD1d ligand alpha-galactosylceramide (alphaGalCer) induces pregnancy loss in mice through an ill-defined mechanism involving TNF, IFN-gamma, and perforin. In this article, we demonstrate that during early gestation, alphaGalCer efficiently induced pregnancy loss in C57BL/6J and BALB/cJ mice in a perforin-dependent manner. In contrast, during midgestation perforin was no longer required for pregnancy loss. Concomitant with the loss of a perforin requirement at midgestation was the emergence of strain-dependent variations in susceptibility to alphaGalCer-induced pregnancy loss. Whereas pregnant C57BL/6J mice remained susceptible to alphaGalCer at midgestation, pregnant BALB/cJ mice were resistant to its effects. Pregnancy loss during midgestation was correlated with dramatically higher serum cytokine levels, including TNF and IL-2, in the susceptible C57BL/6J strain compared with the resistant BALB/cJ strain. Thus, the stage of gestation defined two distinct mechanisms of pregnancy loss: a perforin-dependent mechanism operating at early gestation and a perforin-independent, cytokine-dominated mechanism operating after midgestation. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 12 |
| Volume Number | 103 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2006-03-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Antigens, CD1 Killer Cells, Natural Immunology Premature Birth T-Lymphocytes Animals Antigens, CD1d Galactosylceramides Pharmacology Interleukin-2 Blood Drug Effects Ligands Membrane Glycoproteins Metabolism Mice Mice, Inbred BALB C Mice, Inbred C57BL Perforin Pore Forming Cytotoxic Proteins Pregnancy Genetics Pathology Tumor Necrosis Factor-alpha Research Support, N.I.H., Extramural Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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