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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | De Oliveira, C. Hong, S. Taniguchi, M. Bendelac, A. Gonzalez-aseguinolaza, G. Bruna-romero, O. Tsuji, M. Tomaska, M. Koezuka, Y. Van Kaer, L. Nakayama, T. |
| Description | Author Affiliation: Gonzalez-Aseguinolaza G ( Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, NY 10010, USA.); |
| Abstract | Natural killer T (NKT) cells are a unique population of lymphocytes that coexpress a semiinvariant T cell and natural killer cell receptors, which are particularly abundant in the liver. To investigate the possible effect of these cells on the development of the liver stages of malaria parasites, a glycolipid, alpha-galactosylceramide (alpha-GalCer), known to selectively activate Valpha14 NKT cells in the context of CD1d molecules, was administered to sporozoite-inoculated mice. The administration of alpha-GalCer resulted in rapid, strong antimalaria activity, inhibiting the development of the intrahepatocytic stages of the rodent malaria parasites Plasmodium yoelii and Plasmodium berghei. The antimalaria activity mediated by alpha-GalCer is stage-specific, since the course of blood-stage-induced infection was not inhibited by administration of this glycolipid. Furthermore, it was determined that IFN-gamma is essential for the antimalaria activity mediated by the glycolipid. Taken together, our results provide the clear evidence that NKT cells can mediate protection against an intracellular microbial infection. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 15 |
| Volume Number | 97 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2000-08-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Antimalarials Pharmacology Galactosylceramides Killer Cells, Natural Immunology Lymphocyte Activation Drug Effects Malaria Plasmodium Berghei Plasmodium Yoelii Receptors, Antigen, T-Cell, Alpha-beta T-Lymphocytes Animals Antigens, CD1 Administration & Dosage Interferon-gamma Interleukin-12 Liver Parasitology Mice Mice, Inbred BALB C Mice, Inbred C57BL Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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