NDLI: The role of antigen and IL-12 in sustaining Th1 memory cells in vivo: IL-12 is required to maintain memory/effector Th1 cells sufficient to mediate protection to an infectious parasite challenge.

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The role of antigen and IL-12 in sustaining Th1 memory cells in vivo: IL-12 is required to maintain memory/effector Th1 cells sufficient to mediate protection to an infectious parasite challenge.

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The role of antigen and IL-12 in sustaining Th1 memory cells in vivo: IL-12 is required to maintain memory/effector Th1 cells sufficient to mediate protection to an infectious parasite challenge.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Stobie, L. Prussin, C. Seder, R. A. Glaichenhaus, N. Wu, C. Y. Sacks, D. L. Gurunathan, S.
Description	Author Affiliation: Stobie L ( Clinical Immunology Section, Laboratory of Clinical Investigation, Howard Hughes Medical Institute, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.);
Abstract	IL-12 plays a central role in both the induction and magnitude of a primary Th1 response. A critical question in designing vaccines for diseases requiring Th1 immunity such as Mycobacterium tuberculosis and Leishmania major is the requirements to sustain memory/effector Th1 cells in vivo. This report examines the role of IL-12 and antigen in sustaining Th1 responses sufficient for protective immunity to L. major after vaccination with LACK protein (LP) plus rIL-12 and LACK DNA. It shows that, after initial vaccination with LP plus rIL-12, supplemental boosting with either LP or rIL-12 is necessary but not sufficient to fully sustain long-term Th1 immunity. Moreover, endogenous IL-12 is also shown to be required for the induction, maintenance, and effector phase of the Th1 response after LACK DNA vaccination. Finally, IL-12 is required to sustain Th1 cells and control parasite growth in susceptible and resistant strains of mice during primary and secondary infection. Taken together, these data show that IL-12 is essential to sustain a sufficient number of memory/effector Th1 cells generated in vivo to mediate long-term protection to an intracellular pathogen.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	15
Volume Number	97
Language	English
Publisher	National Academy of Sciences
Publisher Date	2000-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigens, Protozoan Immunology Immunologic Memory Interleukin-12 Leishmania Major Leishmaniasis, Cutaneous Prevention & Control Protozoan Proteins Protozoan Vaccines Th1 Cells Vaccines, DNA Animals Antigens, CD4 Genetics Immunity, Innate Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Time Factors Vaccination Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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