NDLI: The immunodominant T helper 2 (Th2) response elicited in BALB/c mice by the Leishmania LiP2a and LiP2b acidic ribosomal proteins cannot be reverted by strong Th1 inducers.

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The immunodominant T helper 2 (Th2) response elicited in BALB/c mice by the Leishmania LiP2a and LiP2b acidic ribosomal proteins cannot be reverted by strong Th1 inducers.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Iborra, S. Abánades, D. R. Parody, N. Carrión, J. Risueño, R. M. Pineda, M. A. Bonay, P. Alonso, C. Soto, M.
Description	Country affiliation: Spain Author Affiliation: Iborra S ( Centro de Biología Molecular Severo Ochoa, Departamento de Biología Molecular, Facultad de Ciencias, Universidad Autónoma de Madrid, Madrid, Spain.)
Abstract	The search for disease-associated T helper 2 (Th2) Leishmania antigens and the induction of a Th1 immune response to them using defined vaccination protocols is a potential strategy to induce protection against Leishmania infection. Leishmania infantum LiP2a and LiP2b acidic ribosomal protein (P proteins) have been described as prominent antigens during human and canine visceral leishmaniasis. In this study we demonstrate that BALB/c mice infected with Leishmania major develop a Th2-like humoral response against Leishmania LiP2a and LiP2b proteins and that the same response is induced in BALB/c mice when the parasite P proteins are immunized as recombinant molecules without adjuvant. The genetic immunization of BALB/c mice with eukaryotic expression plasmids coding for these proteins was unable to redirect the Th2-like response induced by these antigens, and only the co-administration of the recombinant P proteins with CpG oligodeoxynucleotides (CpG ODN) promoted a mixed Th1/Th2 immune response. According to the preponderance of a Th2 or mixed Th1/Th2 responses elicited by the different regimens of immunization tested, no evidence of protection was observed in mice after challenge with L. major. Although alterations of the clinical outcome were not detected in mice presensitized with the P proteins, the enhanced IgG1 and interleukin (IL)-4 response against total Leishmania antigens in these mice may indicate an exacerbation of the disease.
File Format	HTM / HTML
ISSN	00099104
e-ISSN	13652249
Journal	Clinical & Experimental Immunology
Issue Number	2
Volume Number	150
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2007-11-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Immunology Leishmania Major Immunology Leishmaniasis Vaccines Leishmaniasis, Cutaneous Prevention & Control Protozoan Proteins Th1 Cells Th2 Cells Adjuvants, Immunologic Animals Antibodies, Protozoan Biosynthesis Antigens, Bacterial Antigens, Protozoan Immunoglobulin G Interleukin-4 Mice Mice, Inbred Balb C Oligodeoxyribonucleotides Recombinant Proteins Ribosomal Proteins Vaccines, Dna Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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The immunodominant T helper 2 (Th2) response elicited in BALB/c mice by the Leishmania LiP2a and LiP2b acidic ribosomal proteins cannot be reverted by strong Th1 inducers.

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