NDLI: Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.

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Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.

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Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lim, M. K. Kargul, G. J. Grahovac, M. J. Tanaka, T. S. Pantano, S. Ko, M. S. Nagaraja, R. Wood, W. H. Jaradat, S. A. Becker, K. G. Piao, Y. Doi, H. Wang, X. Sano, Y.
Description	Author Affiliation: Tanaka TS ( Laboratory of Genetics and DNA Array Unit, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224-6820, USA.);
Abstract	cDNA microarray technology has been increasingly used to monitor global gene expression patterns in various tissues and cell types. However, applications to mammalian development have been hampered by the lack of appropriate cDNA collections, particularly for early developmental stages. To overcome this problem, a PCR-based cDNA library construction method was used to derive 52,374 expressed sequence tags from pre- and peri-implantation embryos, embryonic day (E) 12.5 female gonad/mesonephros, and newborn ovary. From these cDNA collections, a microarray representing 15,264 unique genes (78% novel and 22% known) was assembled. In initial applications, the divergence of placental and embryonic gene expression profiles was assessed. At stage E12.5 of development, based on triplicate experiments, 720 genes (6.5%) displayed statistically significant differences in expression between placenta and embryo. Among 289 more highly expressed in placenta, 61 placenta-specific genes encoded, for example, a novel prolactin-like protein. The number of genes highly expressed (and frequently specific) for placenta has thereby been increased 5-fold over the total previously reported, illustrating the potential of the microarrays for tissue-specific gene discovery and analysis of mammalian developmental programs.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	16
Volume Number	97
Language	English
Publisher	National Academy of Sciences
Publisher Date	2000-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Embryo, Mammalian Metabolism Gene Expression Regulation, Developmental Genome Placenta Pregnancy Proteins Genetics Amino Acid Sequence Animals DNA Primers DNA, Complementary Mice Mice, Inbred C57BL Molecular Sequence Data Nucleic Acid Hybridization Pregnancy Chemistry Sequence Homology, Amino Acid Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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