NDLI: Positron emission tomography provides molecular imaging of biological processes.

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Positron emission tomography provides molecular imaging of biological processes.

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Positron emission tomography provides molecular imaging of biological processes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Phelps, M. E.
Description	Author Affiliation: Phelps ME ( Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging, University of California Los Angeles School of Medicine, Box 951735, Los Angeles, CA 90095-1735, USA. mphelps@mednet.ucla.edu);
Abstract	Diseases are biological processes, and molecular imaging with positron emission tomography (PET) is sensitive to and informative of these processes. This is illustrated by detection of biological abnormalities in neurological disorders with no computed tomography or MRI anatomic changes, as well as even before symptoms are expressed. PET whole body imaging in cancer provides the means to (i) identify early disease, (ii) differentiate benign from malignant lesions, (iii) examine all organs for metastases, and (iv) determine therapeutic effectiveness. Diagnostic accuracy of PET is 8-43% higher than conventional procedures and changes treatment in 20-40% of the patients, depending on the clinical question, in lung and colorectal cancers, melanoma, and lymphoma, with similar findings in breast, ovarian, head and neck, and renal cancers. A microPET scanner for mice, in concert with human PET systems, provides a novel technology for molecular imaging assays of metabolism and signal transduction to gene expression, from mice to patients: e.g., PET reporter gene assays are used to trace the location and temporal level of expression of therapeutic and endogenous genes. PET probes and drugs are being developed together-in low mass amounts, as molecular imaging probes to image the function of targets without disturbing them, and in mass amounts to modify the target's function as a drug. Molecular imaging by PET, optical technologies, magnetic resonance imaging, single photon emission tomography, and other technologies are assisting in moving research findings from in vitro biology to in vivo integrative mammalian biology of disease.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	16
Volume Number	97
Language	English
Publisher	National Academy of Sciences
Publisher Date	2000-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Tomography, Emission-Computed Alzheimer Disease Metabolism Animals Brain Gene Expression Mice Neoplasms Parkinson Disease Radioisotopes Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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