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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Terao, M. Mintz, B. |
| Description | Author Affiliation: Terao M ( Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111.); |
| Abstract | Mouse alkaline phosphatase [ALP; orthophosphoric-monoester phosphohydrolase (alkaline optimum), EC 3.1.3.1] was partially purified from placenta. Data obtained by immunoblotting analysis suggested that the primary structure of this enzyme has a much greater homology to that of human and bovine liver ALPs than to the human placental isozyme. Therefore, a full-length cDNA encoding human liver-type ALP was used as a probe to isolate the mouse placental ALP cDNA. The cloned mouse cDNA is 2459 base pairs long and is composed of an open reading frame encoding a 524-amino acid polypeptide that contains a putative signal peptide of 17 amino acids. Homology at the amino acid level of the mouse placental ALP is 90% to the human liver isozyme but only 55% to the human placental counterpart. RNA blot hybridization results indicate that the mouse placental ALP is encoded by a gene identical to the gene expressed in mouse liver, kidney, and teratocarcinoma stem cells. This gene is therefore evolutionarily highly conserved in mouse and human. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 20 |
| Volume Number | 84 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1987-11-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | DNA Genetics Isoenzymes Alkaline Phosphatase Amino Acid Sequence Animals DNA, Recombinant GPI-Linked Proteins Mice Mice, Inbred ICR Molecular Sequence Data Placenta Enzymology Pregnancy Sequence Homology, Nucleic Acid Species Specificity Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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