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A conserved mechanism of retrovirus restriction in mammals.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Stoye, J. P. Bock, M. Towers, G. Takeuchi, Y. Martin, S. Danos, O.
Description	Author Affiliation: Towers G ( Wohl Virion Centre, Windeyer Institute of Medical Sciences, University College London, 46 Cleveland Street, London W1P 6DB, United Kingdom.);
Abstract	The murine Fv1 gene restricts infection by N- or B-tropic murine leukemia viruses at a postentry, preintegration stage. The Fv1-sensitive viruses previously used for the study of Fv1 encode an ecotropic envelope gene and thus only infect rodent cells. Consequently, the study of Fv1 restriction has been carried out solely in mice and murine cell lines. By infection with retroviral vectors containing N- or B-tropic core and pantropic vesicular stomatitis virus-G envelope protein, we now demonstrate that cell lines derived from various mammalian species, including humans, have an Fv1-like retrovirus restriction function, preventing N-tropic vector infection. Like Fv1, restriction is directed at amino acid 110 of the viral capsid protein. In contrast to Fv1, the novel restriction is characterized by the absence of reverse-transcribed viral DNA. We speculate that these activities have been selected for by retroviral epidemics in the distant past.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	22
Volume Number	97
Language	English
Publisher	National Academy of Sciences
Publisher Date	2000-11-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Mammals Virology Retroviridae Genetics 3T3 Cells Animals DNA Primers DNA, Viral Mice Polymerase Chain Reaction Proteins Transcription, Genetic Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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