NDLI: Dual roles of the 11S regulatory subcomplex in condensin functions.

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Dual roles of the 11S regulatory subcomplex in condensin functions.

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Dual roles of the 11S regulatory subcomplex in condensin functions.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kimura, K. Hirano, T.
Description	Author Affiliation: Kimura K ( Cold Spring Harbor Laboratory, P.O. Box 100, Cold Spring Harbor, NY 11724, USA.);
Abstract	Condensin is a multisubunit protein complex that reconfigures DNA structure in an ATP-dependent manner in vitro and plays a central role in mitotic chromosome condensation in Xenopus egg cell-free extracts. The Xenopus 13S condensin complex (13SC) is composed of two subcomplexes: an 8S core subcomplex (8SC) consisting of two structural maintenance of chromosomes (SMC) subunits (XCAP-C and -E) and an 11S regulatory subcomplex (11SR) containing three non-SMC subunits (XCAP-D2, -G, and -H). We report here the biochemical and functional dissection of this chromosome condensation machinery. Although both 8SC and 13SC can bind to DNA in vitro and contain the SMC ATPase subunits, only 13SC is active as a DNA-stimulated ATPase and supports ATP-dependent supercoiling activity. In the cell-free extracts, 13SC is the active form that binds to chromosomes and induces their condensation. Neither 11SR nor 8SC alone is able to bind to chromatin. Our results suggest that the non-SMC subunits have dual roles in the regulation of condensin functions: one is to activate SMC ATPases and the other is to allow the holocomplex to associate with chromatin in a mitosis-specific manner.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	22
Volume Number	97
Language	English
Publisher	National Academy of Sciences
Publisher Date	2000-11-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Adenosine Triphosphatases Metabolism DNA-Binding Proteins Isolation & Purification Adenosine Triphosphate Amino Acid Sequence Animals Cell Extracts Chromatin Chromatography, Affinity Chromosomes Electrophoresis, Polyacrylamide Gel Molecular Sequence Data Multiprotein Complexes Nucleosomes Xenopus Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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