NDLI: The gcm-motif: a novel DNA-binding motif conserved in Drosophila and mammals.

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Mapping the universe in three dimensions.

Astrophysical symmetries.

A brief survey of symmetry in mathematics.

Convex polytopes and quantization of symplectic manifolds.

The role of symmetry in fundamental physics.

Symmetries in geology and geophysics.

Symmetries throughout the sciences. Concluding talk.

Symmetries in bacterial motility.

Symmetries throughout organic evolution.

Symmetry, stability, and dynamics of multidomain and multicomponent protein systems.

Symmetry and the energy landscapes of biomolecules.

Symmetry arguments in chemistry.

New perspectives on forbidden symmetries, quasicrystals, and Penrose tilings.

Five-fold symmetry in crystalline quasicrystal lattices.

From symmetry to asymmetry: phylogenetic patterns of asymmetry variation in animals and their evolutionary significance.

Symmetry in chemistry from the hydrogen atom to proteins.

Improving functional imaging techniques: the dream of a single image for a single mental event.

Nutrition, immunity and infection: from basic knowledge of dietary manipulation of immune responses to practical application of ameliorating suffering and improving survival.

Circadian timekeeping: loops and layers of transcriptional control.

Neurodegenerative diseases and transglutaminase.

Comments on the article 'Persistent confusion of total entropy and chemical system entropy in chemical thermodynamics' [(1996) Proc. Natl. Acad. Sci. USA 93, 7452-7453].

Biosynthesis of vitamin B12: factor IV, a new intermediate in the anaerobic pathway.

Biosynthesis of vitamin B12: concerning the identity of the two-carbon fragment eliminated during anaerobic formation of cobyrinic acid.

Nature knows best: an amazing reaction cascade is uncovered by design and discovery.

Adsorption from a one-dimensional lattice gas and the Brunauer-Emmett-Teller equation.

Detection of a $Yb^{3+}$ binding site in regenerated bacteriorhodopsin that is coordinated with the protein and phospholipid head groups

Protein engineering of Bacillus thuringiensis delta-endotoxin: mutations at domain II of CryIAb enhance receptor affinity and toxicity toward gypsy moth larvae.

Evidence for a recommended dietary allowance for vitamin C from pharmacokinetics: a comment and analysis.

A fusion pore phenotype in mast cells of the ruby-eye mouse.

Three-dimensional structure of human electron transfer flavoprotein to 2.1-Å resolution

Altered recognition mutants of the response regulator PhoB: A new genetic strategy for studying protein–protein interactions

Molecular cloning of a high-affinity receptor for the growth factor-like lipid mediator lysophosphatidic acid from Xenopus oocytes.

Crystal structure of the breakpoint cluster region-homology domain from phosphoinositide 3-kinase p85 alpha subunit.

Identification of surface residues mediating tissue factor binding and catalytic function of the serine protease factor VIIa.

Deoxycytidine kinase and deoxyguanosine kinase of Lactobacillus acidophilus R-26 are colinear products of a single gene.

Phosphohistidyl active sites in polyphosphate kinase of Escherichia coli.

NMR characterization and solution structure determination of the oxidized cytochrome c7 from Desulfuromonas acetoxidans.

Conserved circadian elements in phylogenetically diverse algae.

Distamycin A modulates the sequence specificity of DNA alkylation by duocarmycin A.

Equilibrium constants and free energies in unfolding of proteins in urea solutions.

Conversion of DNA gyrase into a conventional type II topoisomerase.

Characterization and developmental patterns of telomerase expression in plants.

The chemistry of the S-nitrosoglutathione/glutathione system.

The leucine zipper may induce electrophoretic mobility anomalies without DNA bending.

Linking genome and proteome by mass spectrometry: large-scale identification of yeast proteins from two dimensional gels.

The purified Bacillus subtilis tetracycline efflux protein TetA(L) reconstitutes both $tetracycline–cobalt/H^{+}$ and $Na^{+}(K^{+})/H^{+} exchange$

Dominant negative inhibition by fragments of a monomeric enzyme.

A coupled complex of T4 DNA replication helicase (gp41) and polymerase (gp43) can perform rapid and processive DNA strand-displacement synthesis.

Function of RNA secondary structures in transcriptional attenuation of the Bacillus subtilis pyr operon.

Interactions of RecF protein with RecO, RecR, and single-stranded DNA binding proteins reveal roles for the RecF-RecO-RecR complex in DNA repair and recombination.

The change in hydrogen bond strength accompanying charge rearrangement: implications for enzymatic catalysis.

A small nucleolar RNA requirement for site-specific ribose methylation of rRNA in Xenopus.

Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases.

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A global two component signal transduction system that integrates the control of photosynthesis, carbon dioxide assimilation, and nitrogen fixation

Proton long-range migration along protein monolayers and its consequences on membrane coupling.

Ordered water molecules as key allosteric mediators in a cooperative dimeric hemoglobin.

Lipidic cubic phases: a novel concept for the crystallization of membrane proteins.

Pharmacologic shifting of a balance between protein refolding and degradation mediated by Hsp90.

Activation of protein kinase A-independent pathways by Gs alpha in Drosophila.

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Calmodulin activates nuclear protein import: a link between signal transduction and nuclear transport.

Peptides containing glutamine repeats as substrates for transglutaminase-catalyzed cross-linking: relevance to diseases of the nervous system.

Activation of transcription factor AP-2 mediates UVA radiation- and singlet oxygen-induced expression of the human intercellular adhesion molecule 1 gene.

Reciprocal regulation of Gs alpha by palmitate and the beta gamma subunit.

Phospholipase C beta 4 is involved in modulating the visual response in mice.

Mouse cytoplasmic polyadenylylation element binding protein: an evolutionarily conserved protein that interacts with the cytoplasmic polyadenylylation elements of c-mos mRNA.

Complex formation between stage-specific oocyte factors and a Xenopus mRNA localization element.

Presence of a mitochondrial-type 70-kDa heat shock protein in Trichomonas vaginalis suggests a very early mitochondrial endosymbiosis in eukaryotes

A possible mitochondrial gene in the early-branching amitochondriate protist Trichomonas vaginalis.

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cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors.

Yeast homologues of higher eukaryotic TFIID subunits.

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Human trophoblast and choriocarcinoma expression of the growth factor pleiotrophin attributable to germ-line insertion of an endogenous retrovirus.

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The gcm-motif: a novel DNA-binding motif conserved in Drosophila and mammals.

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Assessment of normal and mutant human presenilin function in Caenorhabditis elegans.

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Down-regulation of transcripts for Na channel alpha-SNS in spinal sensory neurons following axotomy.

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Crystallization and identification of an assembly defect of recombinant antenna complexes produced in transgenic tobacco plants.

Isolation and characterization of a tobacco mosaic virus-inducible myb oncogene homolog from tobacco.

'Agrolistic' transformation of plant cells: integration of T-strands generated in planta.

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The gcm-motif: a novel DNA-binding motif conserved in Drosophila and mammals.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hotta, Y. Hosoya, T. Poole, A. M. Akiyama, Y.
Description	Author Affiliation: Akiyama Y ( Department of Physics, Graduate School of Science, Tokyo, Japan.);
Abstract	In the Drosophila nervous system, the glial cells missing gene (gcm) is transiently expressed in glial precursors to switch their fate from the neuronal default to glia. It encodes a novel 504-amino acid protein with a nuclear localization signal. We report here that the GCM protein is a novel DNA-binding protein and that its DNA-binding activity is localized in the N-terminal 181 amino acids. It binds with high specificity to the nucleotide sequence, (A/G)CCCGCAT, which is a novel sequence among known targets of DNA-binding proteins. Eleven such GCM-binding sequences are found in the 5' upstream region of the repo gene, whose expression in early glial cells is dependent on gcm. This suggests that the GCM protein is a transcriptional regulator directly controlling repo. We have also identified homologous genes from human and mouse whose products share a highly conserved N-terminal region with Drosophila GCM. At least one of these was shown to have DNA-binding activity similar to that of GCM. By comparing the deduced amino acid sequences of these gene products, we were able to define the 'gcm motif,' an evolutionarily conserved motif with DNA-binding activity. By PCR amplification, we obtained evidence for the existence of additional gcm-motif genes in mouse as well as in Drosophila. The gcm-motif, therefore, forms a family of novel DNA-binding proteins, and may function in various aspects of cell fate determination.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	25
Volume Number	93
Language	English
Publisher	National Academy of Sciences
Publisher Date	1996-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	DNA-Binding Proteins Genetics Drosophila Neuropeptides Trans-Activators Amino Acid Sequence Animals Conserved Sequence Isolation & Purification Drosophila Proteins Mammals Mice Molecular Sequence Data Polymerase Chain Reaction Sequence Alignment Sequence Analysis Transcription Factors Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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