NDLI: Amphotropic murine leukemia viruses induce spongiform encephalomyelopathy.

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Amphotropic murine leukemia viruses induce spongiform encephalomyelopathy.

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Amphotropic murine leukemia viruses induce spongiform encephalomyelopathy.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Münk, C. Stocking, C. Löhler, J. Just, U. Prassolov, V. Stockschläder, M.
Description	Author Affiliation: Münk C ( Department of Cell and Virus Genetics, Heinrich-Pette-Institut für experimentelle Virologie und Immunologie, Martinistrasse 52, D-20251 Hamburg, Germany.);
Abstract	Recombinants of amphotropic murine leukemia virus (A-MuLV) have found widespread use in retroviral vector systems due to their ability to efficiently and stably infect cells of several different species, including human. Previous work has shown that replication-competent recombinants containing the amphotropic env gene, encoding the major SU envelope glycoprotein that determines host tropism, induce lymphomas in vivo. We show here that these viruses also induce a spongiform encephalomyelopathy in mice inoculated perinatally. This fatal central nervous system disease is characterized by noninflammatory spongiform lesions of nerve and glial cells and their processes, and is associated with moderate astro- and microgliosis. The first clinical symptoms are ataxia, tremor, and spasticity, progressing to complete tetraparesis and incontinence, and finally death of the animal. Sequences within the amphotropic env gene are necessary for disease induction. Coinfection of A-MuLV recombinants with nonneuropathogenic ecotropic or polytropic MuLV drastically increases the incidence, degree, and distribution of the neurodegenerative disorder. The consequence of these results in view of the use of A-MuLV recombinants in the clinic is discussed.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	11
Volume Number	94
Language	English
Publisher	National Academy of Sciences
Publisher Date	1997-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Brain Pathology Leukemia Virus, Murine Pathogenicity Prion Diseases Physiopathology Virology Animals Animals, Newborn DNA Primers Disease Susceptibility Genome, Viral Genetics Isolation & Purification Mice Mice, Inbred BALB C Mice, Inbred DBA Mice, Inbred Strains Polymerase Chain Reaction Recombination, Genetic Retroviridae Infections Species Specificity Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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