NDLI: Peg3/Pw1 promotes p53-mediated apoptosis by inducing Bax translocation from cytosol to mitochondria.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 2000 Volume: 97 Issue: 26

Year: 2000 Volume: 97 Issue: 25

Year: 2000 Volume: 97 Issue: 24

Year: 2000 Volume: 97 Issue: 23

Year: 2000 Volume: 97 Issue: 22

Ecological basis of extinction risk in birds: habitat loss versus human persecution and introduced predators.

Photoperiodic information acquired and stored in vivo is retained in vitro by a circadian oscillator, the avian pineal gland.

A structural basis for drug-induced long QT syndrome

Genome sequence of Halobacterium species NRC-1.

Allosteric, chiral-selective drug binding to DNA.

A conserved mechanism of retrovirus restriction in mammals.

BCR/ABL inhibition by an escort/phosphatase fusion protein

Substrate-dependent mutant complementation to select fatty acid desaturase variants for metabolic engineering of plant seed oils.

Negative hair-bundle stiffness betrays a mechanism for mechanical amplification by the hair cell.

Demonstration of the in vivo interaction of key cell death regulators by structure-based design of second-site suppressors.

Prostitution and the sex discrepancy in reported number of sexual partners.

Functional switching of GABAergic synapses by ryanodine receptor activation

Receptor-mediated endocytosis of soluble and membrane-tethered Sonic hedgehog by Patched-1.

Dual roles of the 11S regulatory subcomplex in condensin functions.

Discovering functional relationships between RNA expression and chemotherapeutic susceptibility using relevance networks.

The visual paired-comparison task as a measure of declarative memory.

The Ebola virus VP35 protein functions as a type I IFN antagonist

A metabolic defect promotes obesity in mice lacking melanocortin-4 receptors.

Cytoplasmic catalytic subunit of protein kinase A mediates cross-repression by NF-kappa B and the glucocorticoid receptor.

Induction of primary NY-ESO-1 immunity: CD8+ T lymphocyte and antibody responses in peptide-vaccinated patients with NY-ESO-1+ cancers.

DNA microarray analysis of gene expression in response to physiological and genetic changes that affect tryptophan metabolism in Escherichia coli.

Regulation of T cell activation, anxiety, and male aggression by RGS2.

ABA activates multiple $Ca^{2+}$ fluxes in stomatal guard cells, triggering vacuolar $K^{+}(Rb^{+})$ release

A Saccharomyces gene family involved in invasive growth, cell-cell adhesion, and mating.

Human lung cancer and p53: the interplay between mutagenesis and selection.

The magnitude distribution of declustered earthquakes in Southern California.

Social enhancement of fitness in yellow-bellied marmots.

Pinpointing when T cell costimulatory receptor CTLA-4 must be engaged to dampen diabetogenic T cells.

Tonsillar memory B cells, latently infected with Epstein-Barr virus, express the restricted pattern of latent genes previously found only in Epstein-Barr virus-associated tumors.

Atmospheric aerosols as prebiotic chemical reactors.

Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha.

Quantitative transcript imaging in normal and heat-shocked Drosophila embryos by using high-density oligonucleotide arrays.

Coupled two-way clustering analysis of gene microarray data.

Altered selectivity in an Arabidopsis metal transporter.

Inhibition of cardiac L-type calcium channels by protein kinase C phosphorylation of two sites in the N-terminal domain

Antimicrobial activity of MHC class I-restricted CD8+ T cells in human tuberculosis.

Unique progressive cleavage mechanism of HIV reverse transcriptase RNase H.

Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta-catenin.

SBE-TAGS: an array-based method for efficient single-nucleotide polymorphism genotyping.

Deoxysugars in glycopeptide antibiotics: enzymatic synthesis of TDP-L-epivancosamine in chloroeremomycin biosynthesis.

Manifold anomalies in gene expression in a vineyard isolate of Saccharomyces cerevisiae revealed by DNA microarray analysis.

X-ray crystal structure of an anti-Buckminsterfullerene antibody fab fragment: biomolecular recognition of C(60).

A viral member of the ERV1/ALR protein family participates in a cytoplasmic pathway of disulfide bond formation.

Phosphorylation-dependent targeting of cAMP response element binding protein to the ubiquitin/proteasome pathway in hypoxia

Binding sites in Escherichia coli dihydrofolate reductase communicate by modulating the conformational ensemble.

Phosphorylation of murine p53 at ser-18 regulates the p53 responses to DNA damage.

Polynucleotide phosphorylase functions both as a 3' right-arrow 5' exonuclease and a poly(A) polymerase in Escherichia coli.

The complex $ATP–Fe^{2+}$ serves as a specific affinity cleavage reagent in $ATP-Mg^{2+}$ sites of Na,K-ATPase: Altered ligation of $Fe^{2+}$ $(Mg^{2+})$ ions accompanies the $E_{1}P→E_{2}P$ conformational change

Origin of mitochondria in relation to evolutionary history of eukaryotic alanyl-tRNA synthetase.

Localizing proteins in the cell from their phylogenetic profiles.

Suppression of angiogenesis by lentiviral delivery of PEX, a noncatalytic fragment of matrix metalloproteinase 2.

Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm.

Frataxin activates mitochondrial energy conversion and oxidative phosphorylation.

Mass spectrometry and immobilized enzymes for the screening of inhibitor libraries.

Fossilized high pressure from the Earth's deep interior: the coesite-in-diamond barometer.

Prostate formation in a marsupial is mediated by the testicular androgen 5 alpha-androstane-3 alpha,17 beta-diol.

Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A.

Cytochrome c binding to Apaf-1: the effects of dATP and ionic strength.

The pachytene checkpoint prevents accumulation and phosphorylation of the meiosis-specific transcription factor Ndt80.

The self-same beat of time's wide wings.

Can allosteric regulation be predicted from structure?

Channel structure and drug-induced cardiac arrhythmias.

Facilitating structural transitions in DNA.

Ecological mechanisms of extinction.

Auditory neuroscience: development, transduction, and integration.

Notch signaling in the development of the inner ear: lessons from Drosophila.

Molecular genetics of pattern formation in the inner ear: do compartment boundaries play a role?

Patterning of the mammalian cochlea.

Cellular studies of auditory hair cell regeneration in birds.

Hair cell recovery in mitotically blocked cultures of the bullfrog saccule.

Two mechanisms for transducer adaptation in vertebrate hair cells.

Cochlear mechanisms from a phylogenetic viewpoint.

Mechanical bases of frequency tuning and neural excitation at the base of the cochlea: comparison of basilar-membrane vibrations and auditory-nerve-fiber responses in chinchilla.

The spatial and temporal representation of a tone on the guinea pig basilar membrane.

Molecular mechanisms of sound amplification in the mammalian cochlea.

Putting ion channels to work: mechanoelectrical transduction, adaptation, and amplification by hair cells.

Detection of synchrony in the activity of auditory nerve fibers by octopus cells of the mammalian cochlear nucleus.

Linear and nonlinear pathways of spectral information transmission in the cochlear nucleus.

Cellular mechanisms for resolving phase ambiguity in the owl's inferior colliculus.

Subdivisions of auditory cortex and processing streams in primates.

Mechanisms and streams for processing of 'what' and 'where' in auditory cortex.

The corticofugal system for hearing: recent progress.

Traces of learning in the auditory localization pathway.

Plasticity in the neural coding of auditory space in the mammalian brain.

Spatial processing in the auditory cortex of the macaque monkey.

Song selectivity and sensorimotor signals in vocal learning and production.

On cortical coding of vocal communication sounds in primates.

A new view of language acquisition.

Attributes of an alluvial river and their relation to water policy and management.

Neuromelanin biosynthesis is driven by excess cytosolic catecholamines not accumulated by synaptic vesicles

Bounds for cell entries in contingency tables given marginal totals and decomposable graphs.

How important are entropic contributions to enzyme catalysis?

Furin-mediated processing in the early secretory pathway: sequential cleavage and degradation of misfolded insulin receptors.

A census of glutamine/asparagine-rich regions: implications for their conserved function and the prediction of novel prions.

Miniaturized metalloproteins: application to iron-sulfur proteins.

Molecular basis for modulation of biological function by alternate splicing of the Wilms' tumor suppressor protein

A single amino acid substitution (F363I) converts the regiochemistry of the spearmint (-)-limonene hydroxylase from a C6- to a C3-hydroxylase.

Biochemistry, mutagenesis, and oligomerization of DsRed, a red fluorescent protein from coral.

The structure of the chromophore within DsRed, a red fluorescent protein from coral.

Molecular spectroscopy and dynamics of intrinsically fluorescent proteins: coral red (dsRed) and yellow (Citrine).

Replication by a single DNA polymerase of a stretched single-stranded DNA.

Nonglassy kinetics in the folding of a simple single-domain protein.

Anatomy of protein structures: visualizing how a one-dimensional protein chain folds into a three-dimensional shape.

Peg3/Pw1 promotes p53-mediated apoptosis by inducing Bax translocation from cytosol to mitochondria.

Hematopoietic reconstitution of SLP-76 corrects hemostasis and platelet signaling through alpha IIb beta 3 and collagen receptors.

Creatine kinase, an ATP-generating enzyme, is required for thrombin receptor signaling to the cytoskeleton.

Skeletal muscle deformity and neuronal disorder in Trio exchange factor-deficient mouse embryos.

Direct genetic demonstration of G alpha 13 coupling to the orphan G protein-coupled receptor G2A leading to RhoA-dependent actin rearrangement.

Antagonistic role of vega1 and bozozok/dharma homeobox genes in organizer formation.

Parameters of self-organization in Hydra aggregates.

Clonogenic hepatoblasts, common precursors for hepatocytic and biliary lineages, are lacking classical major histocompatibility complex class I antigen.

PCGEM1, a prostate-specific gene, is overexpressed in prostate cancer.

Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation.

Hematopoietic progenitor cells grow on 3T3 fibroblast monolayers that overexpress growth arrest-specific gene-6 (GAS6).

Intracellular antibody-caspase-mediated cell killing: an approach for application in cancer therapy.

Visualizing gene expression by whole-body fluorescence imaging.

A secreted Salmonella protein induces a proinflammatory response in epithelial cells, which promotes neutrophil migration.

Reduction of axonal caliber does not alleviate motor neuron disease caused by mutant superoxide dismutase 1.

Development and persistence of kindling epilepsy are impaired in mice lacking glial cell line-derived neurotrophic factor family receptor alpha 2.

Constitutive expression of the neuron-restrictive silencer factor (NRSF)/REST in differentiating neurons disrupts neuronal gene expression and causes axon pathfinding errors in vivo.

Role of microtubules in the intracellular distribution of tobacco mosaic virus movement protein.

Failure to handle more than one internal representation in visual detection tasks.

Year: 2000 Volume: 97 Issue: 21

Year: 2000 Volume: 97 Issue: 20

Year: 2000 Volume: 97 Issue: 19

Year: 2000 Volume: 97 Issue: 18

Year: 2000 Volume: 97 Issue: 17

Year: 2000 Volume: 97 Issue: 16

Year: 2000 Volume: 97 Issue: 15

Year: 2000 Volume: 97 Issue: 14

Year: 2000 Volume: 97 Issue: 13

Year: 2000 Volume: 97 Issue: 12

Year: 2000 Volume: 97 Issue: 11

Year: 2000 Volume: 97 Issue: 10

Year: 2000 Volume: 97 Issue: 9

Year: 2000 Volume: 97 Issue: 8

Year: 2000 Volume: 97 Issue: 7

Year: 2000 Volume: 97 Issue: 6

Year: 2000 Volume: 97 Issue: 5

Year: 2000 Volume: 97 Issue: 4

Year: 2000 Volume: 97 Issue: 3

Year: 2000 Volume: 97 Issue: 2

Year: 2000 Volume: 97 Issue: 1

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Peg3/Pw1 promotes p53-mediated apoptosis by inducing Bax translocation from cytosol to mitochondria.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Deng, Y. Wu, X.
Description	Author Affiliation: Deng Y ( Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.);
Abstract	Mitochondria is believed to play a central role in p53-mediated apoptosis. However, the signal transduction pathways leading to mitochondria remain unclear. Here, we report that translocation of Bax protein from cytosol to mitochondria is required for p53-induced apoptosis. Cytosolic Bax is unable to induce apoptosis, and blocking Bax translocation inhibits cell death. Expression of Bcl-2 blocks cytochrome c release and apoptosis but has no effect on Bax translocation, suggesting that Bax translocation acts upstream of Bcl-2. We further demonstrate that Peg3/Pw1, a protein up-regulated in p53-mediated cell death process, induces Bax translocation independent of apoptosis. The results suggest that Bax translocation represents an important regulatory step in p53-mediated apoptosis, and Peg3/Pw1 functions as a modulator downstream of p53 to regulate Bax redistribution in the cells, thus favoring the cellular decision toward apoptosis over growth arrest following p53 induction.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	22
Volume Number	97
Language	English
Publisher	National Academy of Sciences
Publisher Date	2000-11-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Apoptosis Physiology Cytosol Metabolism Mitochondria Proteins Proto-Oncogene Proteins C-bcl-2 Proto-Oncogene Proteins Transcription Factors Tumor Suppressor Protein P53 Blotting, Western Cell Line Cytochrome c Group Antagonists & Inhibitors Protein Transport Subcellular Fractions Bcl-2-Associated X Protein Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in