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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Williamson, R. A. Firme, L. Parren, P. W. Gilden, D. H. Owens, G. P. Burgoon, M. P. Leclerc, E. Carlson, S. Corboy, J. Sanna, P. P. Ghausi, O. Burton, D. R. |
| Description | Author Affiliation: Williamson RA ( Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA. anthony@scripps.edu); |
| Abstract | Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of unknown cause that afflicts the central nervous system. MS is typified by a highly clonally restricted antigen-driven antibody response that is confined largely to the central nervous system. The major antigenic targets of this response and the role of antibody in disease pathogenesis remain unclear. To help resolve these issues, we cloned the IgG repertoire directly from active plaque and periplaque regions in MS brain and from B cells recovered from the cerebrospinal fluid of a patient with MS with subacute disease. We found that high-affinity anti-DNA antibodies are a major component of the intrathecal IgG response in the patients with MS that we studied. Furthermore, we show DNA-specific monoclonal antibodies rescued from two subjects with MS as well as a DNA-specific antibody rescued from an individual suffering from systemic lupus erythematosus bound efficiently to the surface of neuronal cells and oligodendrocytes. For two of these antibodies, cell-surface recognition was DNA dependent. Our findings indicate that anti-DNA antibodies may promote important neuropathologic mechanisms in chronic inflammatory disorders, such as MS and systemic lupus erythematosus. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 4 |
| Volume Number | 98 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2001-02-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Antibodies, Antinuclear Immunology B-Lymphocytes Brain Multiple Sclerosis Blood Cerebrospinal Fluid Immunoglobulin Fab Fragments Genetics Immunoglobulin G Immunoglobulin Kappa-Chains Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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