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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Onuma, Yasuko Gehring, Walter J. Takahashi, Shuji Asashima, Makoto Kurata, Shoichiro |
| Description | Author Affiliation: Onuma Y ( Department of Life Sciences, Core Research for Evolution Science and Technology Project, University of Tokyo, Komaba, Meguro-ku, Tokyo 153-8902, Japan.); |
| Abstract | Loss of Pax 6 function leads to an eyeless phenotype in both mammals and insects, and ectopic expression of both the Drosophila and the mouse gene leads to the induction of ectopic eyes in Drosophila, which suggested to us that Pax 6 might be a universal master control gene for eye morphogenesis. Here, we report the reciprocal experiment in which the RNAs of the Drosophila Pax 6 homologs, eyeless and twin of eyeless, are transferred into a vertebrate embryo; i.e., early Xenopus embryos at the 2- and 16-cell stages. In both cases, ectopic eye structures are formed. To understand the genetic program specifying eye morphogenesis, we have analyzed the regulatory mechanisms of Pax 6 expression that initiates eye development. Previously, we have demonstrated that Notch signaling regulates the expression of eyeless and twin of eyeless in Drosophila. Here, we show that in Xenopus, activation of Notch signaling also induces eye-related gene expression, including Pax 6, in isolated animal caps. In Xenopus embryos, the activation of Notch signaling causes eye duplications and proximal eye defects, which are also induced by overexpression of eyeless and twin of eyeless. These findings indicate that the gene regulatory cascade is similar in vertebrates and invertebrates. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 4 |
| Volume Number | 99 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2002-02-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Drosophila Proteins Eye Embryology Homeodomain Proteins Chemistry Physiology Membrane Proteins Metabolism Animals DNA-Binding Proteins Biosynthesis Drosophila Evolution, Molecular Eye Proteins Gene Expression Regulation, Developmental Genetic Vectors In Situ Hybridization Paired Box Transcription Factors Protein Structure, Tertiary RNA RNA, Messenger Receptors, Notch Repressor Proteins Retina Reverse Transcriptase Polymerase Chain Reaction Signal Transduction Time Factors Trans-Activators Xenopus Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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