NDLI: Lune/eye gone, a Pax-like protein, uses a partial paired domain and a homeodomain for DNA recognition.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1998 Volume: 95 Issue: 26

Year: 1998 Volume: 95 Issue: 25

Year: 1998 Volume: 95 Issue: 24

Year: 1998 Volume: 95 Issue: 23

Plant gene silencing regularized.

Tuberculosis: old problems and new approaches.

DSHP: a 'power bar' for sustained immune responses?

Higher-plant phytochrome: 'I used to date histidine, but now I prefer serine'.

Bone homeostasis.

Prions. (Journal: Proceedings of the National Academy of Sciences of the United States of America Volume: 95 Issue: 23)

The thermal explosion revisited.

Polyazamacrolides from ladybird beetles: ring-size selective oligomerization.

On representations of finite type.

Synthesis of medium-chain-length polyhydroxyalkanoates in arabidopsis thaliana using intermediates of peroxisomal fatty acid beta-oxidation.

Identification of a structural determinant for resistance to beta-lactam antibiotics in Gram-positive bacteria.

Propagating structure of Alzheimer's beta-amyloid(10-35) is parallel beta-sheet with residues in exact register.

Mitochondrial stress protein recognition of inactivated dehydrogenases during mammalian cell death

An autonomous folding unit mediates the assembly of two-stranded coiled coils.

A general mechanism for regulation of access to the translocon: competition for a membrane attachment site on ribosomes.

Mössbauer spectroscopy as a tool for the study of activation/inactivation of the transcription regulator FNR in whole cells of Escherichia coli.

Crystal structure of the ribosomal RNA domain essential for binding elongation factors.

Retinoic acid X receptor in the diploblast, Tripedalia cystophora.

Oligomerization of activated D- and L-guanosine mononucleotides on templates containing D- and L-deoxycytidylate residues.

Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice.

Defects in embryonic hindbrain development and fetal resorption resulting from vitamin A deficiency in the rat are prevented by feeding pharmacological levels of all-trans-retinoic acid.

The reactive site loop of the serpin SCCA1 is essential for cysteine proteinase inhibition.

Unblocking of chain-terminated primer by HIV-1 reverse transcriptase through a nucleotide-dependent mechanism.

Biosynthetic control of molecular weight in the polymerization of the octasaccharide subunits of succinoglycan, a symbiotically important exopolysaccharide of Rhizobium meliloti.

TAFII mutations disrupt Dorsal activation in the Drosophila embryo.

Metal ion-mediated substrate-assisted catalysis in type II restriction endonucleases

Aminoacylation of tRNA in the evolution of an aminoacyl-tRNA synthetase.

Long-distance transcriptional enhancement by the histone acetyltransferase PCAF.

lambda Rap protein is a structure-specific endonuclease involved in phage recombination.

The lipid phosphatase activity of PTEN is critical for its tumor supressor function.

HIV-1 tat transactivator recruits p300 and CREB-binding protein histone acetyltransferases to the viral promoter.

A streptavidin mutant with altered ligand-binding specificity.

Topoisomerase II-mediated site-directed alkylation of DNA by psorospermin and its use in mapping other topoisomerase II poison binding sites.

Capping and methylation of mRNA by purified recombinant VP4 protein of bluetongue virus.

A transcriptional activating region with two contrasting modes of protein interaction.

Chemical synthesis of the precursor molecule of the Aequorea green fluorescent protein, subsequent folding, and development of fluorescence.

MRG1, the product of a melanocyte-specific gene related gene, is a cytokine-inducible transcription factor with transformation activity.

A 55-kDa protein isolated from human cells shows DNA glycosylase activity toward 3,N4-ethenocytosine and the G/T mismatch.

Roles of SecG in ATP- and SecA-dependent protein translocation.

Dynamics of fluorescence fluctuations in green fluorescent protein observed by fluorescence correlation spectroscopy.

Electrostatic interaction between helical macromolecules in dense aggregates: an impetus for DNA poly- and meso-morphism.

TROSY in triple-resonance experiments: new perspectives for sequential NMR assignment of large proteins.

Limited internal friction in the rate-limiting step of a two-state protein folding reaction.

Large-scale protein structure modeling of the Saccharomyces cerevisiae genome.

Ab initio calculation of electronic coupling in the photosynthetic reaction center.

Proton uptake controls electron transfer in cytochrome c oxidase.

Impairing follicle-stimulating hormone (FSH) signaling in vivo: targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance.

Caspase-3 controls both cytoplasmic and nuclear events associated with Fas-mediated apoptosis in vivo.

An HP1-like protein is missing from transcriptionally silent micronuclei of Tetrahymena

Characterization of two patched receptors for the vertebrate hedgehog protein family.

A novel structure involved in the formation of liver endothelial cell fenestrae revealed by using the actin inhibitor misakinolide.

Chloride is an allosteric effector of copper assembly for the yeast multicopper oxidase Fet3p: An unexpected role for intracellular chloride channels

v-K-ras leads to preferential farnesylation of p21(ras) in FRTL-5 cells: multiple interference with the isoprenoid pathway.

Myosin II localization during cytokinesis occurs by a mechanism that does not require its motor domain.

Involvement of focal adhesion kinase in invasin-mediated uptake.

Oncogene-dependent apoptosis is mediated by caspase-9.

Graded transcriptional response to different concentrations of a single transactivator.

ADP-ribosylation factor and phosphatidic acid levels in Golgi membranes during budding of coatomer-coated vesicles.

Specific interaction of mutant p53 with regions of matrix attachment region DNA elements (MARs) with a high potential for base-unpairing.

Retinoic acid alters the intracellular trafficking of the mannose-6-phosphate/insulin-like growth factor II receptor and lysosomal enzymes.

Genetic instability of cancer cells is proportional to their degree of aneuploidy.

Termination of signaling by protease-activated receptor-1 is linked to lysosomal sorting.

Transgenic Drosophila expressing human amyloid precursor protein show gamma-secretase activity and a blistered-wing phenotype.

RNA helicase A is essential for normal gastrulation.

AP-2-null cells disrupt morphogenesis of the eye, face, and limbs in chimeric mice.

Lune/eye gone, a Pax-like protein, uses a partial paired domain and a homeodomain for DNA recognition.

Derivation of pluripotent stem cells from cultured human primordial germ cells.

Polyandrous females discriminate against previous mates.

Dispersal of first 'workers' in social wasps: causes and implications of an alternative reproductive strategy.

Chemical phenotype matching between a plant and its insect herbivore.

Origins and antiquity of X-linked triallelic color vision systems in New World monkeys.

Working memory constrains human cooperation in the Prisoner's Dilemma.

Carcinogen-induced loss of heterozygosity at the Aprt locus in somatic cells of the mouse.

Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome

Ribosomes can slide over and beyond 'hungry' codons, resuming protein chain elongation many nucleotides downstream.

The AMPA receptor subunit GluR-B in its Q/R site-unedited form is not essential for brain development and function.

The three yeast A kinases have specific signaling functions in pseudohyphal growth.

Reciprocal subtraction differential RNA display: an efficient and rapid procedure for isolating differentially expressed gene sequences.

Characterization of the Saccharomyces cerevisiae ERG26 gene encoding the C-3 sterol dehydrogenase (C-4 decarboxylase) involved in sterol biosynthesis.

Rump white inversion in the mouse disrupts dipeptidyl aminopeptidase-like protein 6 and causes dysregulation of Kit expression.

Inhibition of interferon gamma induced interleukin 12 production: a potential mechanism for the anti-inflammatory activities of tumor necrosis factor.

Characteristics of virus-specific CD8(+) T cells in the liver during the control and resolution phases of influenza pneumonia.

Mechanisms of beta cell death in diabetes: a minor role for CD95.

T helper type 2 inflammatory disease in the absence of interleukin 4 and transcription factor STAT6.

Impaired liver regeneration in inducible nitric oxide synthasedeficient mice.

Dissociation between bone resorption and bone formation in osteopenic transgenic mice.

Catalytically inactive lipoprotein lipase expression in muscle of transgenic mice increases very low density lipoprotein uptake: direct evidence that lipoprotein lipase bridging occurs in vivo.

Adeno-associated viral-mediated catalase expression suppresses optic neuritis in experimental allergic encephalomyelitis

A model for spontaneous B-lineage lymphomas in IgHmu-HOX11 transgenic mice.

NF-kappaB activation provides the potential link between inflammation and hyperplasia in the arthritic joint.

Peptide inhibitors of HIV-1 protease and viral infection of peripheral blood lymphocytes based on HIV-1 Vif.

The BRCA2 gene product functionally interacts with p53 and RAD51.

Anti-CD14 mAb treatment provides therapeutic benefit after in vivo exposure to endotoxin.

Modeling the impact of global tuberculosis control strategies.

c-Myc target gene specificity is determined by a post-DNAbinding mechanism.

Transient cardiac expression of constitutively active Galphaq leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways.

ExoY, an adenylate cyclase secreted by the Pseudomonas aeruginosa type III system.

Hybrid Ty1/HIV-1 elements used to detect inhibitors and monitor the activity of HIV-1 reverse transcriptase.

U94 of human herpesvirus 6 is expressed in latently infected peripheral blood mononuclear cells and blocks viral gene expression in transformed lymphocytes in culture.

Vaccinia locomotion in host cells: evidence for the universal involvement of actin-based motility sequences ABM-1 and ABM-2.

A family of phase-variable restriction enzymes with differing specificities generated by high-frequency gene rearrangements.

Leading role of thalamic over cortical neurons during postinhibitory rebound excitation.

Functional redundancy of acetylcholinesterase and neuroligin in mammalian neuritogenesis

Estrogen alters behavior and forebrain c-fos expression in ovariectomized rats subjected to the forced swim test.

Interaction of batrachotoxin with the local anesthetic receptor site in transmembrane segment IVS6 of the voltage-gated sodium channel.

KATP channel inhibition by ATP requires distinct functional domains of the cytoplasmic C terminus of the pore-forming subunit.

Virus resistance and gene silencing in plants can be induced by simultaneous expression of sense and antisense RNA.

A PII-like protein in Arabidopsis: putative role in nitrogen sensing.

Concerted biosynthesis of an insect elicitor of plant volatiles.

Eukaryotic phytochromes: light-regulated serine/threonine protein kinases with histidine kinase ancestry.

Movement analysis in infancy may be useful for early diagnosis of autism.

Perceptual learning reflects external noise filtering and internal noise reduction through channel reweighting.

The origin of the Na-Dene.

Year: 1998 Volume: 95 Issue: 22

Year: 1998 Volume: 95 Issue: 21

Year: 1998 Volume: 95 Issue: 20

Year: 1998 Volume: 95 Issue: 19

Year: 1998 Volume: 95 Issue: 18

Year: 1998 Volume: 95 Issue: 17

Year: 1998 Volume: 95 Issue: 16

Year: 1998 Volume: 95 Issue: 15

Year: 1998 Volume: 95 Issue: 14

Year: 1998 Volume: 95 Issue: 13

Year: 1998 Volume: 95 Issue: 12

Year: 1998 Volume: 95 Issue: 11

Year: 1998 Volume: 95 Issue: 10

Year: 1998 Volume: 95 Issue: 9

Year: 1998 Volume: 95 Issue: 8

Year: 1998 Volume: 95 Issue: 7

Year: 1998 Volume: 95 Issue: 6

Year: 1998 Volume: 95 Issue: 5

Year: 1998 Volume: 95 Issue: 4

Year: 1998 Volume: 95 Issue: 3

Year: 1998 Volume: 95 Issue: 2

Year: 1998 Volume: 95 Issue: 1

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Lune/eye gone, a Pax-like protein, uses a partial paired domain and a homeodomain for DNA recognition.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wallen, R. V. Kalionis, B. Jun, S. Goriely, A. Desplan, C.
Description	Author Affiliation: Jun S ( Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA.);
Abstract	Pax proteins, characterized by the presence of a paired domain, play key regulatory roles during development. The paired domain is a bipartite DNA-binding domain that contains two helix-turn-helix domains joined by a linker region. Each of the subdomains, the PAI and RED domains, has been shown to be a distinct DNA-binding domain. The PAI domain is the most critical, but in specific circumstances, the RED domain is involved in DNA recognition. We describe a Pax protein, originally called Lune, that is the product of the Drosophila eye gone gene (eyg). It is unique among Pax proteins, because it contains only the RED domain. eyg seems to play a role both in the organogenesis of the salivary gland during embryogenesis and in the development of the eye. A high-affinity binding site for the Eyg RED domain was identified by using systematic evolution of ligands by exponential enrichment techniques. This binding site is related to a binding site previously identified for the RED domain of the Pax-6 5a isoform. Eyg also contains another DNA-binding domain, a Prd-class homeodomain (HD), whose palindromic binding site is similar to other Prd-class HDs. The ability of Pax proteins to use the PAI, RED, and HD, or combinations thereof, may be one mechanism that allows them to be used at different stages of development to regulate various developmental processes through the activation of specific target genes.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	23
Volume Number	95
Language	English
Publisher	National Academy of Sciences
Publisher Date	1998-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	DNA-Binding Proteins Genetics DNA Drosophila Genes, Insect Nuclear Proteins Transcription Factors Amino Acid Sequence Animals Binding Sites Metabolism Embryology Embryo, Nonmammalian Eye Proteins Gene Expression Regulation, Developmental Homeodomain Proteins Molecular Sequence Data B-Cell-Specific Activator Protein Paired Box Transcription Factors Protein Binding Repressor Proteins Sequence Alignment Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in