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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Mcnaught, Kevin St P. Jenkins, Bruce G. Bjorklund, Lars M. Kim, Kwang-soo Isacson, Ole Wahlestedt, Claes Andersson, Therese Sánchez-pernaute, Rosario Chung, Sangmi Chen, Iris Yin Ching Brownell, Anna-liisa |
| Description | Author Affiliation: Bjorklund LM ( Udall Parkinson's Disease Research Center of Excellence, Neuroregeneration Laboratories, and Molecular Neurobiology Laboratory, McLean Hospital/Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA.); |
| Abstract | Although implantation of fetal dopamine (DA) neurons can reduce parkinsonism in patients, current methods are rudimentary, and a reliable donor cell source is lacking. We show that transplanting low doses of undifferentiated mouse embryonic stem (ES) cells into the rat striatum results in a proliferation of ES cells into fully differentiated DA neurons. ES cell-derived DA neurons caused gradual and sustained behavioral restoration of DA-mediated motor asymmetry. Behavioral recovery paralleled in vivo positron emission tomography and functional magnetic resonance imaging data demonstrating DA-mediated hemodynamic changes in the striatum and associated brain circuitry. These results demonstrate that transplanted ES cells can develop spontaneously into DA neurons. Such DA neurons can restore cerebral function and behavior in an animal model of Parkinson's disease. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 4 |
| Volume Number | 99 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2002-02-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Dopamine Metabolism Embryo, Mammalian Cytology Neurons Transplantation Parkinson Disease Therapy Stem Cells Adrenergic Agents Pharmacology Amphetamine Animals Cell Culture Techniques Cell Transplantation Dopamine Agents Immunohistochemistry Ligands Oxidopamine Time Factors Tomography, Emission-Computed Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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