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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Yang, Otto O. Nguyen, Tung Bristol, Greg Hong, Teresa Zack, Jerome A. Waring, Alan J. Boo, Lee Ming Zhao, Chengquan Lehrer, Robert I. Cole, Alexander M. |
| Description | Author Affiliation: Cole AM ( Department of Medicine, AIDS Institute, University of California School of Medicine, Los Angeles, CA 90095, USA.); |
| Abstract | Human bone marrow expresses a pseudogene that encodes an antimicrobial peptide homologous to rhesus monkey circular minidefensins (delta-defensins). We prepared the putative ancestral human peptide by solid-phase synthesis and named it 'retrocyclin.' Retrocyclin did not cause direct inactivation of HIV-1, and its modest antibacterial properties resembled those of its rhesus homologs. Nevertheless, retrocyclin had a remarkable ability to inhibit proviral DNA formation and to protect immortalized and primary human CD4(+) lymphocytes from in vitro infection by both T-tropic and M-tropic strains of HIV-1. Confocal fluorescent microscopy studies performed with BODIPY-FL-labeled RC-101, a close analog of retrocyclin, showed that the peptide formed patch-like aggregates on the surface of CD4(+) cells. These findings suggest that retrocyclin interferes with an early stage of HIV-1 infection and that retrocyclin-like agents might be useful topical agents to prevent sexually acquired HIV-1 infections. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 4 |
| Volume Number | 99 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2002-02-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Bone Marrow Cells Metabolism CD4-Positive T-Lymphocytes Virology Defensins Chemistry HIV-1 Peptides Animals Boron Compounds Pharmacology Circular Dichroism DNA, Complementary DNA, Viral Dose-Response Relationship, Drug Enzyme-Linked Immunosorbent Assay Macaca Mulatta Microscopy, Confocal Models, Biological Molecular Sequence Data Oligonucleotides, Antisense Polymerase Chain Reaction Proteins Reverse Transcriptase Polymerase Chain Reaction Sequence Homology, Amino Acid Time Factors Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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