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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kersey, Farrell R. Merkel, Timothy J. Jones, Stephen W. Luft, J. Christopher Bear, James E. Shields, Adam R. Wu, Huali Zamboni, William C. Desimone, Joseph M. Napier, Mary Wang, Andrew Z. Herlihy, Kevin P. |
| Description | Author Affiliation: Merkel TJ ( Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599, USA.); |
| Abstract | It has long been hypothesized that elastic modulus governs the biodistribution and circulation times of particles and cells in blood; however, this notion has never been rigorously tested. We synthesized hydrogel microparticles with tunable elasticity in the physiological range, which resemble red blood cells in size and shape, and tested their behavior in vivo. Decreasing the modulus of these particles altered their biodistribution properties, allowing them to bypass several organs, such as the lung, that entrapped their more rigid counterparts, resulting in increasingly longer circulation times well past those of conventional microparticles. An 8-fold decrease in hydrogel modulus correlated to a greater than 30-fold increase in the elimination phase half-life for these particles. These results demonstrate a critical design parameter for hydrogel microparticles. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 2 |
| Volume Number | 108 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2011-01-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Erythrocytes Cytology Hydrogel Chemistry Animals Biocompatible Materials Biomimetics Drug Carriers Equipment Design Kinetics Materials Testing Mice Mice, Inbred BALB C Microscopy, Fluorescence Particle Size Polymers Time Factors Tissue Distribution Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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