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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Jäck, Hans-martin Porstner, Martina Mathews, Martina Reth, Michael Roth, Edith Schuh, Wolfgang Kahn, Mark L. Winkelmann, Rebecca Sandrock, Lena Hobeika, Elias |
| Description | Author Affiliation: Winkelmann R ( Division of Molecular Immunology, Nikolaus-Fiebiger-Center, Department of Internal Medicine III, Friedrich-Alexander-University Erlangen-Nürnberg, D-91054 Erlangen, Germany.); |
| Abstract | Krüppel-like factor 2 (KLF2) controls T lymphocyte egress from lymphoid organs by regulating sphingosin-1 phosphate receptor 1 (S1Pr1). Here we show that this is not the case for B cells. Instead, KLF2 controls homeostasis of B cells in peripheral lymphatic organs and homing of plasma cells to the bone marrow, presumably by controlling the expression of ß(7)-integrin. In mice with a B cell-specific deletion of KLF2, S1Pr1 expression on B cells was only slightly affected. Accordingly, all splenic B cell subsets including B1 cells were present, but their numbers were increased with a clear bias for marginal zone (MZ) B cells. In contrast, fewer peyers patches harboring fewer B cells were found, and fewer B1 cells in the peritoneal cavity as well as recirculating B cells in the bone marrow were detected. Upon thymus-dependent immunization, IgG titers were diminished, and antigen-specific plasma cells were absent in the bone marrow, although numbers of antigen-specific splenic plasmablasts were normal. KLF2 plays also a role in determining the identity of follicular B cells, as KLF2-deficient follicular B cells showed calcium responses similar to those of MZ B cells and failed to down-regulate MZ B cell signature genes, such as CD21 and CXCR7. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 2 |
| Volume Number | 108 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2011-01-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | B-Lymphocytes Cytology Kruppel-Like Transcription Factors Metabolism Plasma Cells Animals Antigens, CD43 Biosynthesis Bone Marrow Cells Calcium Fingolimod Hydrochloride Gene Deletion Integrin Beta Chains L-Selectin Mice Models, Biological Propylene Glycols Pharmacology Receptors, IgE Receptors, Lysosphingolipid Sphingosine Analogs & Derivatives Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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