NDLI: Biocompatibility and characterization of a peptide amphiphile hydrogel for applications in peripheral nerve regeneration.

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Biocompatibility and characterization of a peptide amphiphile hydrogel for applications in peripheral nerve regeneration.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Black, Katie A. Lin, Brian F. Wonder, Emily A. Desai, Seema S. Chung, Eun Ji Ulery, Bret D. Katari, Ravi S. Tirrell, Matthew V.
Description	Author Affiliation: Black KA ( 1 Department of Bioengineering, University of California Berkeley , Berkeley, California.)
Abstract	Peripheral nerve injury is a debilitating condition for which new bioengineering solutions are needed. Autografting, the gold standard in treatment, involves sacrifice of a healthy nerve and results in loss of sensation or function at the donor site. One alternative solution to autografting is to use a nerve guide conduit designed to physically guide the nerve as it regenerates across the injury gap. Such conduits are effective for short gap injuries, but fail to surpass autografting in long gap injuries. One strategy to enhance regeneration inside conduits in long gap injuries is to fill the guide conduits with a hydrogel to mimic the native extracellular matrix found in peripheral nerves. In this work, a peptide amphiphile (PA)-based hydrogel was optimized for peripheral nerve repair. Hydrogels consisting of the PA C16GSH were compared with a commercially available collagen gel. Schwann cells, a cell type important in the peripheral nerve regenerative cascade, were able to spread, proliferate, and migrate better on C16GSH gels in vitro when compared with cells seeded on collagen gels. Moreover, C16GSH gels were implanted subcutaneously in a murine model and were found to be biocompatible, degrade over time, and support angiogenesis without causing inflammation or a foreign body immune response. Taken together, these results help optimize and instruct the development of a new synthetic hydrogel as a luminal filler for conduit-mediated peripheral nerve repair.
File Format	HTM / HTML
ISSN	21524947
e-ISSN	21524955
DOI	10.1089/ten.TEA.2014.0297
Journal	Tissue Engineering Part A
Issue Number	7-8
Volume Number	21
Language	English
Publisher	Mary Ann Liebert, Inc.
Publisher Date	2015-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Biotechnology Biocompatible Materials Pharmacology Hydrogel Nerve Regeneration Physiology Peptides Peripheral Nerves Surface-active Agents Animals Antibody Formation Drug Effects Cell Movement Cell Proliferation Cell Survival Collagen Gels Materials Testing Mechanical Phenomena Mice, Inbred Balb C Chemistry Schwann Cells Cytology Ultrastructure Research Support, Non-u.s. Gov't Research Support, U.s. Gov't, Non-p.h.s.
Content Type	Text
Resource Type	Article

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Schwann Cells: Development and Role in Nerve Repair.

A rolled sheet of collagen gel with cultured Schwann cells: model of nerve conduit to enhance neurite growth.

Schwann cell proliferation during Wallerian degeneration is not necessary for regeneration and remyelination of the peripheral nerves: axon-dependent removal of newly generated Schwann cells by apoptosis.

Laminin γ1 is critical for Schwann cell differentiation, axon myelination, and regeneration in the peripheral nerve

Application of Hybrid Electrically Conductive Hydrogels Promotes Peripheral Nerve Regeneration

Evaluation of the chitosan/glycerol-beta-phosphate disodium salt hydrogel application in peripheral nerve regeneration.

Highly permeable genipin-cross-linked gelatin conduits enhance peripheral nerve regeneration.

Nogo-A expressed in Schwann cells impairs axonal regeneration after peripheral nerve injury

Tight junctions in Schwann cells of peripheral myelinated axons

Biocompatibility and characterization of a peptide amphiphile hydrogel for applications in peripheral nerve regeneration.

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