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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Meyer-hoffert, Ulf Henriques-normark, Birgitta Kline, Kimberly A. Schröder, Jens M. Normark, Staffan Hultgren, Scott J. Liew, Tze Horng Kandaswamy, Kumaravel Caparon, Michael G. Wang, Charles Y. Huston-warren, Emily Hultenby, Kjell |
| Description | Author Affiliation: Kandaswamy K ( Interdisciplinary Graduate School and School of Biological Sciences, Singapore Centre on Environmental Life Sciences Engineering, Nanyang Technological University, Singapore, 637551.); |
| Abstract | Virulence factor secretion and assembly occurs at spatially restricted foci in some Gram-positive bacteria. Given the essentiality of the general secretion pathway in bacteria and the contribution of virulence factors to disease progression, the foci that coordinate these processes are attractive antimicrobial targets. In this study, we show in Enterococcus faecalis that SecA and Sortase A, required for the attachment of virulence factors to the cell wall, localize to discrete domains near the septum or nascent septal site as the bacteria proceed through the cell cycle. We also demonstrate that cationic human ß-defensins interact with E. faecalis at discrete septal foci, and this exposure disrupts sites of localized secretion and sorting. Modification of anionic lipids by multiple peptide resistance factor, a protein that confers antimicrobial peptide resistance by electrostatic repulsion, renders E. faecalis more resistant to killing by defensins and less susceptible to focal targeting by the cationic antimicrobial peptides. These data suggest a paradigm in which focal targeting by antimicrobial peptides is linked to their killing efficiency and to disruption of virulence factor assembly. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 50 |
| Volume Number | 110 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2013-12-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Adenosine Triphosphatases Metabolism Aminoacyltransferases Bacterial Proteins Cysteine Endopeptidases Enterococcus Faecalis Membrane Transport Proteins Virulence Factors Biosynthesis Beta-Defensins DNA Primers Genetics Fluorescent Antibody Technique Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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