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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lerman, Joshua A. Feist, Adam M. Orth, Jeffrey D. Aziz, Ramy K. Charusanti, Pep Palsson, Bernhard Ø. Monk, Jonathan M. Premyodhin, Ned |
| Description | Author Affiliation: Monk JM ( Department of NanoEngineering and Bioengineering and Program in Bioinformatics, University of California, San Diego, La Jolla, CA 92093.); |
| Abstract | Genome-scale models (GEMs) of metabolism were constructed for 55 fully sequenced Escherichia coli and Shigella strains. The GEMs enable a systems approach to characterizing the pan and core metabolic capabilities of the E. coli species. The majority of pan metabolic content was found to consist of alternate catabolic pathways for unique nutrient sources. The GEMs were then used to systematically analyze growth capabilities in more than 650 different growth-supporting environments. The results show that unique strain-specific metabolic capabilities correspond to pathotypes and environmental niches. Twelve of the GEMs were used to predict growth on six differentiating nutrients, and the predictions were found to agree with 80% of experimental outcomes. Additionally, GEMs were used to predict strain-specific auxotrophies. Twelve of the strains modeled were predicted to be auxotrophic for vitamins niacin (vitamin B3), thiamin (vitamin B1), or folate (vitamin B9). Six of the strains modeled have lost biosynthetic pathways for essential amino acids methionine, tryptophan, or leucine. Genome-scale analysis of multiple strains of a species can thus be used to define the metabolic essence of a microbial species and delineate growth differences that shed light on the adaptation process to a particular microenvironment. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 50 |
| Volume Number | 110 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2013-12-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Adaptation, Biological Genetics Escherichia Coli Genetic Variation Genome, Bacterial Metabolic Networks And Pathways Nutritional Physiological Phenomena Computational Biology Decision Trees Physiology Genes, Bacterial Models, Genetic Phylogeny Shigella Species Specificity Systems Biology Comparative Study Research Support, N.I.H., Extramural Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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