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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Trikka, Fotini A. Roussis, Vassilios Georgantea, Panagiota Makris, Antonios M. Athanasakoglou, Anastasia Loupassaki, Sofia Ioannou, Efstathia Kampranis, Sotirios C. Ignea, Codruta |
| Description | Author Affiliation: Ignea C ( Department of Biochemistry, School of Medicine, University of Crete, Heraklion 71003, Greece); Athanasakoglou A ( Department of Biochemistry, School of Medicine, University of Crete, Heraklion 71003, Greece); Ioannou E ( Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Athens 15771, Greece); Georgantea P ( Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Athens 15771, Greece); Trikka FA ( Institute of Applied Biosciences-Centre for Research and Technology Hellas, Thermi 57001, Thessaloniki, Greece); Loupassaki S ( Mediterranean Agronomic Institute of Chania, Chania 73100, Greece.); Roussis V ( Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Athens 15771, Greece); Makris AM ( Institute of Applied Biosciences-Centre for Research and Technology Hellas, Thermi 57001, Thessaloniki, Greece); Kampranis SC ( Department of Biochemistry, School of Medicine, University of Crete, Heraklion 71003, Greece); |
| Abstract | Synthetic biology approaches achieving the reconstruction of specific plant natural product biosynthetic pathways in dedicated microbial 'chassis' have provided access to important industrial compounds (e.g., artemisinin, resveratrol, vanillin). However, the potential of such production systems to facilitate elucidation of plant biosynthetic pathways has been underexplored. Here we report on the application of a modular terpene production platform in the characterization of the biosynthetic pathway leading to the potent antioxidant carnosic acid and related diterpenes in Salvia pomifera and Rosmarinus officinalis.Four cytochrome P450 enzymes are identified (CYP76AH24, CYP71BE52, CYP76AK6, and CYP76AK8), the combined activities of which account for all of the oxidation events leading to the biosynthesis of the major diterpenes produced in these plants. This approach develops yeast as an efficient tool to harness the biotechnological potential of the numerous sequencing datasets that are increasingly becoming available through transcriptomic or genomic studies. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 13 |
| Volume Number | 113 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2016-04-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Diterpenes, Abietane Biosynthesis Antioxidants Chemistry Metabolism Biosynthetic Pathways Biotechnology Cytochrome P-450 Enzyme System Genetics Metabolic Engineering Plant Proteins Recombinant Proteins Rosmarinus Saccharomyces Cerevisiae Salvia Synthetic Biology Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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