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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Aoki, Kana Maeda, Fumiyo Uchida, Seiichi Nagasako, Tomoya Mochizuki, Yuki Ikenouchi, Junichi |
| Description | Author Affiliation: Aoki K ( Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka 819-0395, Japan); Maeda F ( Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka 819-0395, Japan); Nagasako T ( Department of Advanced Information Technology, Kyushu University, Fukuoka 819-0395, Japan); Mochizuki Y ( Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka 819-0395, Japan); Uchida S ( Department of Advanced Information Technology, Kyushu University, Fukuoka 819-0395, Japan); Ikenouchi J ( Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka 819-0395, Japan); |
| Abstract | The actin cytoskeleton usually lies beneath the plasma membrane. When the membrane-associated actin cytoskeleton is transiently disrupted or the intracellular pressure is increased, the plasma membrane detaches from the cortex and protrudes. Such protruded membrane regions are called blebs. However, the molecular mechanisms underlying membrane blebbing are poorly understood. This study revealed that epidermal growth factor receptor kinase substrate 8 (Eps8) and ezrin are important regulators of rapid actin reassembly for the initiation and retraction of protruded blebs. Live-cell imaging of membrane blebbing revealed that local reassembly of actin filaments occurred at Eps8- and activated ezrin-positive foci of membrane blebs. Furthermore, we found that a RhoA-ROCK-Rnd3 feedback loop determined the local reassembly sites of the actin cortex during membrane blebbing. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 13 |
| Volume Number | 113 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2016-04-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Actin Cytoskeleton Metabolism Cell Membrane Rho GTP-Binding Proteins RhoA GTP-Binding Protein Chemistry Adaptor Proteins, Signal Transducing Genetics Cell Line Cytoskeletal Proteins Feedback, Physiological Green Fluorescent Proteins Microscopy, Fluorescence Rho-Associated Kinases Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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