NDLI: Proteins from eight eukaryotic cytochrome P-450 families share a segmented region of sequence similarity.

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Proteins from eight eukaryotic cytochrome P-450 families share a segmented region of sequence similarity.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kalb, V. F. Loper, J. C.
Description	Author Affiliation: Kalb VF ( Department of Microbiology and Molecular Genetics, University of Cincinnati College of Medicine, OH 45267-0524.);
Abstract	Proteins from eight eukaryotic families in the cytochrome P-450 superfamily share one region of sequence similarity. This region begins 275-310 amino acids from the amino terminus of each P-450, continues for approximately 170 residues, and ends 35-50 amino acids before the carboxyl terminus. The region can be divided into four domains of sequence similarity, each possessing its own pattern of invariant, conserved, and variable amino acids. The four domains are 56, 20, 59, and 28 residues long and are connected by three shorter segments of limited sequence similarity. The number of residues in these short segments varies with the P-450 protein but ranges from 0 to 20 residues. Consensus sequences based on these similarities can be used to determine whether the sequence of an unidentified peptide resembles that expected for a P-450. Sequence similarities between proteins sometimes reflect constraints imposed by the requirements of a common function. The fourth domain of the P-450s, for example, contains an invariant cysteine that provides the axial thiolate ligand to the heme iron. Other relationships between the four domains and P-450 function can be examined by in vitro mutagenic procedures that alter the conserved amino acids or modify the distance between domains.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	19
Volume Number	85
Language	English
Publisher	National Academy of Sciences
Publisher Date	1988-11-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cytochrome P-450 Enzyme System Isoenzymes Adrenal Cortex Enzymology Amino Acid Sequence Animals Liver Molecular Sequence Data Pseudomonas Saccharomyces Cerevisiae Structure-Activity Relationship Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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