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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Wilkerson, Jeremy Graham, Jalina A. Vasquez-opazo, Gustavo A. Hanson, Jessica L. Leary, Christopher J. Rose, Gary J. Alluri, Rishi K. |
| Description | Author Affiliation: Alluri RK ( Department of Biology, University of Utah, Salt Lake City, UT 84112); Rose GJ ( Department of Biology, University of Utah, Salt Lake City, UT 84112); Hanson JL ( Department of Biology, University of Utah, Salt Lake City, UT 84112); Leary CJ ( Department of Biology, University of Mississippi, Oxford, MS 38677); Vasquez-Opazo GA ( Department of Biology, University of Utah, Salt Lake City, UT 84112); Graham JA ( Neuroscience Program, University of California, Davis, CA 95616); Wilkerson J ( TalkingApe.org, Redwood City, CA 94063.); |
| Abstract | Sound duration is important in acoustic communication, including speech recognition in humans. Although duration-selective auditory neurons have been found, the underlying mechanisms are unclear. To investigate these mechanisms we combined in vivo whole-cell patch recordings from midbrain neurons, extraction of excitatory and inhibitory conductances, and focal pharmacological manipulations. We show that selectivity for short-duration stimuli results from integration of short-latency, sustained inhibition with delayed, phasic excitation; active membrane properties appeared to amplify responses to effective stimuli. Blocking GABAA receptors attenuated stimulus-related inhibition, revealed suprathreshold excitation at all stimulus durations, and decreased short-pass selectivity without changing resting potentials. Blocking AMPA and NMDA receptors to attenuate excitation confirmed that inhibition tracks stimulus duration and revealed no evidence of postinhibitory rebound depolarization inherent to coincidence models of duration selectivity. These results strongly support an anticoincidence mechanism of short-pass selectivity, wherein inhibition and suprathreshold excitation show greatest temporal overlap for long duration stimuli. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 13 |
| Volume Number | 113 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2016-04-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Mesencephalon Physiology Neurons Acoustic Stimulation Animals Auditory Perception Auditory Threshold GABA-A Receptor Antagonists Pharmacology Cytology Models, Biological Drug Effects Patch-Clamp Techniques Rana Pipiens Receptors, AMPA Antagonists & Inhibitors Receptors, GABA-A Receptors, N-Methyl-D-Aspartate Time Factors Research Support, N.I.H., Extramural Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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