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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Golasik, Magdalena Wodowski, Grzegorz Gomólka, Ewa Herman, Malgorzata Piekoszewski, Wojciech |
| Description | Country affiliation: Poland Author Affiliation: Golasik M ( Department of Analytical Chemistry, Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Krakow, Poland.); Wodowski G ( Outpatients Clinic for Drug Prevention and Treatment of Addicts, Sw. Katarzyny 3, 31-063 Krakow, Poland.); Gomólka E ( Laboratory of Analytical Toxicology and Therapeutic Drug Monitoring, Faculty of Medicine Jagiellonian University, Kopernika 15b, 31-501 Krakow, Poland.); Herman M ( Department of Analytical Chemistry, Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Krakow, Poland.); Piekoszewski W ( Department of Analytical Chemistry, Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Krakow, Poland) |
| Abstract | Chronic exposure even to low doses of manganese may lead to development of neurological syndrome similar to parkinsonism. The aim of this research is to assess the possibility of manganese poisoning based on the level of metal in the urine of long-term methcathinone users from Poland. Graphite furnace atomic absorption spectroscopy (GFAAS) was used to determine manganese in urine, while the detection of the psychoactive drugs was performed by high-performance liquid chromatography (HPLC). Results of survey on longitudinal patterns of drug use showed that users of traditional illicit drugs now turn to cheaper alternatives, such as methcathinone. Parkinsonian features were observed in almost half of methcathinone users. The subjects had a higher mean level of Mn in their urine (8.68±9.27 µg L(-1)) than the controls (4.27±1.91 µg L(-1)). The presence of numerous psychoactive substances (in unchanged forms and their metabolites) was confirmed in all of the samples, with only one exception. The elevated level of manganese in urine (in 29.2% of patients) can be used as a primary marker of recent methcathinone administration, especially in the case of long time intravenous drug users where blood sampling is complicated. |
| File Format | HTM / HTML |
| ISSN | 0946672X |
| Issue Number | 3 |
| Journal | Journal of Trace Elements in Medicine and Biology |
| Volume Number | 28 |
| e-ISSN | 18783252 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-07-01 |
| Publisher Place | Germany |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Metabolism Discipline Environmental Health Manganese Urine Propiophenones Administration & Dosage Humans Parkinsonian Disorders Spectrophotometry, Atomic Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry Molecular Medicine Inorganic Chemistry |
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