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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Celik, Ismail Suzek, Huseyin |
| Description | Country affiliation: Turkey Author Affiliation: Celik I ( Department of Biology, Science and Lettes Faculty, Yuzuncu Yil University, 65080 Van, Turkey.) |
| Abstract | In this study, the effects of dichlorvos (DIC) at sublethal concentration on malondialdehyde (MDA) content and antioxidant defense system (ADS) such as reduced glutathione (GSH), glutathione reductase (GR), superoxide dismutase (SOD), and glutathione-S-transferase (GST) in various tissues of rats exposed to 0.0225 and 0.0450 millimole (mmol) DIC in drinking water were administered orally to rats ad libitum for 28 days continuously. MDA significantly increased in all the tissues except in the lungs of rats treated with both dosages of DIC. With regard to the ADS, GR significantly decreased in the erythrocytes whereas it did not change in the other tissues with two dosages of DIC. SOD activity significantly increased in the all tissues treated with both dosages of DIC. GST activity significantly increased in all the tissues except in the erythrocytes, spleen, and lungs treated with 0.0225mmol. Meanwhile, GSH depletion in the liver and heart of rats treated with 0.0225mmol and all the tissues except in the brain and kidney of rats treated with 0.0450mmol of DIC were found to be significant. The observations presented led us to conclude that the administrations of DIC promote MDA content and fluctuate in the ADS in rats during the exposure. |
| File Format | HTM / HTML |
| ISSN | 01476513 |
| Issue Number | 3 |
| Volume Number | 72 |
| e-ISSN | 10902414 |
| Journal | Ecotoxicology and Environmental Safety |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2009-03-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Sciences Antioxidants Physiology Dichlorvos Toxicity Erythrocytes Drug Effects Insecticides Oxidative Stress Administration, Oral Animals Body Weight Dose-response Relationship, Drug Metabolism Glutathione Glutathione Reductase Glutathione Transferase Heart Lipid Peroxidation Liver Malondialdehyde Myocardium Rats Rats, Sprague-dawley Superoxide Dismutase Toxicity Tests Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pollution Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health |
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