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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | El-Gerbed, Mohamed S. A. |
| Description | Country affiliation: Egypt Author Affiliation: El-Gerbed MS ( Department of Zoology, Faculty of Science, Damanhour University, Egypt.) |
| Abstract | Deltamethrin is globally used in crop protection and control of malaria and other vector-borne diseases. It has a potent insecticidal activity with an appreciable safety margin. However, a number of studies have demonstrated nephrotoxicity of deltamethrin in mammalian and nonmammalian species. Lycopene, a carotenoid occurring naturally in tomatoes, has attracted considerable attention as an antioxidant. This study was focused on investigating the possible protective effect of coadministration of lycopene on deltamethrin toxicity. In this study, male albino rats were divided into four groups of 10 animals each: group I served as control, which received standard diet; group II received oral administration of deltamethrin (1.28 mg/kg per day) for 30 days; group III received both deltamethrin and lycopene (1 mg/kg per day); group IV received lycopene (1 mg/kg per day). After the experiment, the animals were anesthetized and the cytokine, tumor necrosis factor- (TNF- ), in the serum was measured; the kidney was taken for histological and ultrastructural studies. Deltamethrin significantly increased the TNF- . The histopathological examination of kidney showed mild necrotic changes. Ultrastructural changes in renal proximal tubules of deltamethrin-treated group included an increased number and irregular shape of mitochondria with sparse fragmented cristae, serious ultrastructural lesions in renal proximal tubular lining cells, vacuolar degeneration in the epithelial cells, increased number of lysosomes and loss of apical microvilli. In addition, focal segmental thickening and the duplication of glomerular basement membrane and podocyte changes were observed. Histopathological and ultrastructural study showed some protective effect of lycopene on kidney tissues. |
| File Format | HTM / HTML |
| ISSN | 07482337 |
| Issue Number | 2 |
| Volume Number | 30 |
| e-ISSN | 14770393 |
| Journal | Toxicology and Industrial Health |
| Language | English |
| Publisher | Sage Publications |
| Publisher Date | 2014-03-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Occupational Medicine Discipline Toxicology Carotenoids Pharmacology Insecticides Adverse Effects Kidney Drug Effects Nitriles Pyrethrins Animals Body Weight Fibrosis Chemically Induced Pathology Ultrastructure Male Microscopy, Electron, Transmission Rats Tumor Necrosis Factor-alpha Metabolism Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology |
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