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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Bourogaa, Ezzeddine Jarraya, Raoudha Mezghani Nciri, Riadh Damak, Mohamed Elfeki, Abdelfattah |
| Description | Country affiliation: Tunisia Author Affiliation: Bourogaa E ( 1Laboratoire d'Ecophysiologie Animale, Faculté des Sciences de Sfax, University of Sfax, Sfax, Tunisie.) |
| Abstract | Aqueous extract (AE) of Hammada scoparia leaves was chemically characterized and its hepatoprotective activities were investigated in vivo in rat model. Wistar rats were treated daily with 35% ethanol solution (3 g/kg/day) during 4 weeks and fed with basal diet or basal diet containing AE (200 mg/kg/day). Control rats were treated with saline solution and fed with basal diet. The bioactivity of AE against ethanol-induced oxidative stress in rat liver was studied in order to explore its hepatoprotective effects. H. scoparia extract used at 200 mg/kg body weight significantly prevented the effects of ethanol, which induced a hepatic pathological damage and increased the levels of the serum markers of the enzymes such as alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP). Concomitantly, with these changes, this extract also prevented ethanol-induced oxidative stress in the rat liver as evidenced by the decreased lipid peroxidation level, a considerable decrease in the activities of AST, ALT and ALP and restoring the activities of antioxidant enzymes: superoxide dismutase, catalase and glutathione peroxidase. These biochemical changes were consistent with histopathological observations suggesting marked hepatoprotective effect of the AE of H. scoparia. |
| File Format | HTM / HTML |
| ISSN | 07482337 |
| Issue Number | 2 |
| Volume Number | 30 |
| e-ISSN | 14770393 |
| Journal | Toxicology and Industrial Health |
| Language | English |
| Publisher | Sage Publications |
| Publisher Date | 2014-03-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Occupational Medicine Discipline Toxicology Amaranthaceae Chemistry Ethanol Adverse Effects Liver Cytology Phytochemicals Pharmacology Plant Extracts Plant Leaves Alanine Transaminase Blood Alkaline Phosphatase Animals Aspartate Aminotransferases Body Weight Drug Effects Catalase Metabolism Drug-induced Liver Injury Drug Therapy Pathology Glutathione Peroxidase Lipid Peroxidation Male Organ Size Oxidative Stress Rats Rats, Wistar Superoxide Dismutase Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology |
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