NDLI: Charakterisierung von ENU-Mausmutanten. Tiermodelle für menschliche Erkrankungen mittels morphologischer und molekularer Methoden.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wagner, S. Calzada-Wack, J. Rosemann, M. Becker, L. Tost, M. Silva-Buttkus, P. Klein-Rodewald, T. Fuchs, H. Neff, F. Hrabé de Angelis, M. Esposito, I.
Description	Author Affiliation: Wagner S ( Institut für Experimentelle Genetik, München.)
Abstract	Following sequencing of the human genome there are new challenges to decipher the knowledge concerning gene function and the role of gene interactions and pathways leading to disease. Mouse models have proven to be an ideal tool for this purpose. Point mutations induced by chemical mutagenesis by N-ethyl-N-nitrosourea (ENU) offer possibilities for the analysis of the phenotypic outcome of a single base pair exchange on the entire organism. The Munich ENU mouse mutagenesis project is part of the worldwide efforts to obtain mutations for each gene. The generation of new alleles or allelic series offers relevant insights into the relevance of single gene sections. Various mouse models for human diseases have been generated by a systematic large-scale genome-wide phenotyping screen in the last decade. This work illustrates how the implementation of the ENU mouse mutagenesis project with gene identification and parallel high-throughput screening is taking advantage of local cooperation with experienced phenotyping groups at the Helmholtz Zentrum München, leading to major advances in the functional analysis of the mammalian genome.
File Format	HTM / HTML
ISSN	01728113
Issue Number	Suppl 2
Volume Number	31
e-ISSN	14321963
Journal	Der Pathologe
Language	German
Publisher	Springer
Publisher Date	2010-10-01
Publisher Place	Germany
Access Restriction	Subscribed
Subject Keyword	Discipline Pathology Alkylating Agents Pharmacology Disease Models, Animal Ethylnitrosourea Mice, Mutant Strains Genetics Point Mutation Alleles Animals Base Pairing Genetic Diseases, Inborn Genome, Human Genome-wide Association Study Humans Mice Mutagenesis Phenotype English Abstract Journal Article
Alternative Title	Characterization of ENU-mutant mice. Animal models for human diseases using morphological and molecular methods
Content Type	Text
Resource Type	Article
Subject	Pathology and Forensic Medicine

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