NDLI: Mikrosatelliteninstabilität. Ein neuer prädiktiver Marker (?).

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Dietmaier, W.
Description	Author Affiliation: Dietmaier W ( Institut für Pathologie/Zentrum für molekularpathologische Diagnostik, Universität Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg. wolfgang.dietmaier@klinik.uni-regensburg.de)
Abstract	Microsatellite instability (MSI) is a hallmark of hereditary non-polyposis colorectal cancer (HNPCC), but also occurs in about 12%-15% of sporadic colorectal cancer (CRC) where it is a consequence of an epigenetic inactivation of MLH1. High frequency MSI (MSI-H; i.e. at least two of five specified microsatellite markers show instability) was shown in a large meta-analysis and in recent trials to be a positive prognostic marker for overall survival in CRC. MSI-H or mismatch repair deficiency (MMRD) was also shown to be a marker for ineffectiveness of adjuvant 5-fluorouracil (5-FU) based chemotherapy in CRC. At present, there are no guidelines defining the need for microsatellite analysis before chemotherapy. However, studies published to date provide data suggesting that MSI-H CRC patients should not receive adjuvant chemotherapy, with the exception of patients with other factors or poor prognosis (e.g. T4 tumors, G3/G4 status, blood or lymphatic vessel invasion). MSI or MMRD testing can contribute to a more individualized therapy of CRC and should be performed prior to planned 5-FU monotherapy or adjuvant chemotherapy in a non-metastatic setting.
File Format	HTM / HTML
ISSN	01728113
Issue Number	Suppl 2
Volume Number	31
e-ISSN	14321963
Journal	Der Pathologe
Language	German
Publisher	Springer
Publisher Date	2010-10-01
Publisher Place	Germany
Access Restriction	Subscribed
Subject Keyword	Discipline Pathology Tumor Markers, Biological Genetics Colorectal Neoplasms, Hereditary Nonpolyposis Pathology Colorectal Neoplasms Microsatellite Instability Adaptor Proteins, Signal Transducing Antimetabolites, Antineoplastic Therapeutic Use Chemotherapy, Adjuvant Drug Therapy Dna Mismatch Repair Drug Resistance, Neoplasm Epigenesis, Genetic Fluorouracil Humans Neoplasm Staging Nuclear Proteins Prognosis Journal Article
Alternative Title	Microsatellite instability. A new predictive marker (?)
Content Type	Text
Resource Type	Article
Subject	Pathology and Forensic Medicine

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