NDLI: Klonale Verwandtschaft von Hodgkin-Lymphomen und deren Rezidiven.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Obermann, E. C. Müller, N. Rufle, A. Menter, T. Dirnhofer, S. Tzankov, A.
Description	Author Affiliation: Obermann EC ( Institut für Pathologie, Universitätsspital Basel, Schönbeinstr. 40, 4031 Basel, Schweiz. EObermann@uhbs.ch)
Abstract	In this study, we investigated whether recurrences of classical Hodgkin's lymphoma (HL) are true relapses arising from the primary tumour or clonally unrelated secondary neoplasias. Formalin-fixed, paraffin-embedded tissue specimens of eleven patients with recurrent HL were analyzed. Hodgkin and Reed-Sternberg cells were microdissected after immunohistochemical staining for CD30 using laser-capture technique. Immunoglobulin heavy chain (IgH) gene fragment lengths were analyzed applying consensus FR3 and J primers. Two early relapses after the first HL diagnosis were clonally related to the initial tumour, while three of four early recurrences after a first or second relapse were not. Three patients presenting with late relapses had clonally unrelated neoplasms. Therefore, we conclude that recurrent HL may represent a novel neoplasm, a finding which might play a role in clinical decision-making.
File Format	HTM / HTML
ISSN	01728113
Issue Number	Suppl 2
Volume Number	31
e-ISSN	14321963
Journal	Der Pathologe
Language	German
Publisher	Springer
Publisher Date	2010-10-01
Publisher Place	Germany
Access Restriction	Subscribed
Subject Keyword	Discipline Pathology Clone Cells Pathology Hodgkin Disease Genetics Immunoglobulin Heavy Chains Neoplasm Recurrence, Local Gene Expression Regulation, Neoplastic Herpesvirus 4, Human Humans Reed-sternberg Cells English Abstract Journal Article
Alternative Title	Clonal relationship of Hodgkin lymphoma and its recurrence
Content Type	Text
Resource Type	Article
Subject	Pathology and Forensic Medicine

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