NDLI: 'Dangerous liaisons' im Prostatakarzinom. Klinische und biologische Bedeutung rekurrenter Genfusionen.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Perner, S.
Description	Author Affiliation: Perner S ( Institut für Pathologie, Comprehensive Cancer Center, Universitätsklinikum Tübingen, Liebermeisterstr. 8, 72076 Tübingen. sven.perner1972@gmail.com)
Abstract	Prostate cancer is a common and clinically heterogeneous disease. Understanding the biology of prostate cancer is necessary to best determinate the risk of disease progression and develop novel therapeutic approaches to prevent or slow down disease progression. The recent discovery and subsequent characterization of recurrent gene rearrangements of ETS genes - most frequently ERG - in the majority of prostate cancers is a milestone in translational prostate cancer research. Although multiple molecular alterations have been detected in prostate cancer, a detailed understanding of gene fusion in prostate cancer should help explain the clinical and biologic diversity in addition to providing a rationale for a molecular sub-classification of the disease. This review describes the path from the identification of common ETS gene rearrangements in prostate cancer to possible applications in the treatment of patients, on to the potential scientific implications arising from their discovery.
File Format	HTM / HTML
ISSN	01728113
Issue Number	Suppl 2
Volume Number	31
e-ISSN	14321963
Journal	Der Pathologe
Language	German
Publisher	Springer
Publisher Date	2010-10-01
Publisher Place	Germany
Access Restriction	Subscribed
Subject Keyword	Discipline Pathology Gene Rearrangement Genetics Oncogene Fusion Prostatic Neoplasms Pathology Proto-oncogene Proteins C-ets Serine Endopeptidases Trans-activators Cell Transformation, Neoplastic Exons Gene Expression Regulation, Neoplastic Genotype Humans Male Prognosis Prostate Journal Article Review
Alternative Title	Dangerous liaisons in prostate cancer. Clinical and biological implications of recurrent gene fusions
Content Type	Text
Resource Type	Article
Subject	Pathology and Forensic Medicine

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in