NDLI: Erythrocytes as Controllers of Perfusion Distribution in the Microvasculature of Skeletal Muscle

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Erythrocytes as Controllers of Perfusion Distribution in the Microvasculature of Skeletal Muscle

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sprague, R. S. Bowles, E. A. Achilleus, D. Ellsworth, M. L.
Description	Country affiliation: United States Author Affiliation: Sprague RS ( Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St. Louis, MO 63104, USA. spraguer@slu.edu)
Abstract	In 1929, August Krogh identified the matching of oxygen $(O_{2})$ supply with demand in skeletal muscle as a fundamental physiological process. In the intervening decades, much research has been focused on elucidating the mechanisms by which this important process occurs. For any control system to be effective, there must be a means by which the need is determined and a mechanism by which that information is coupled to an appropriate response. The focus of this review is to highlight current research in support of the hypothesis that the mobile erythrocyte, when exposed to reduced $O_{2}$ tension, releases ATP in a controlled manner. This ATP interacts with purinergic receptors on the endothelium producing both local and conducted vasodilation enabling the erythrocyte to distribute perfusion to precisely match $O_{2}$ delivery with need in skeletal muscle. If this is an important mechanism for normal physiological control of microvascular perfusion, defects in this process would be anticipated to have pathophysiological consequences. Individuals with either type 2 diabetes (DM2) or pre-diabetes have microvascular dysfunction that contributes to morbidity and mortality. DM2 erythrocytes and erythrocytes incubated with insulin at levels similar to those seen in pre-diabetes fail to release ATP in response to reduced $O_{2}$ tension. Knowledge of the components of the signal transduction pathway for low $O_{2}-induced$ ATP release suggest novel therapeutic approaches to ameliorating this defect. Although the erythrocyte may be but one component of the complex $O_{2}$ delivery process, it appears to play an important role in distributing oxygen within the microvasculature.
File Format	HTM / HTML
ISSN	17481708
e-ISSN	17481716
DOI	10.1111/j.1748-1716.2010.02182.x
Journal	Acta Physiologica
Issue Number	3
Volume Number	202
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2011-07-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Physiology Erythrocytes Physiology Microvessels Muscle, Skeletal Blood Supply Oxygen Blood Regional Blood Flow Adenosine Triphosphate Metabolism Animals Caffeine Pharmacology Diabetes Mellitus, Type 2 Physiopathology Drug Effects Peptides Tetrazoles Vasodilator Agents Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Physiology

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