NDLI: Transcellular and Paracellular Pathways of Transepithelial Fluid Secretion in Malpighian (renal) Tubules of the Yellow Fever Mosquito Aedes aegypti

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Transcellular and Paracellular Pathways of Transepithelial Fluid Secretion in Malpighian (renal) Tubules of the Yellow Fever Mosquito Aedes aegypti

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Beyenbach, K. W. Piermarini, P. M.
Description	Country affiliation: United States Author Affiliation: Beyenbach KW ( Department of Biomedical Sciences, VRT 8004, Cornell University, Ithaca, NY, USA. kwb1@cornell.edu)
Abstract	Isolated Malpighian tubules of the yellow fever mosquito secrete NaCl and KCl from the peritubular bath to the tubule lumen via active transport of $Na^{+}$ and $K^{+}$ by principal cells. Lumen-positive transepithelial voltages are the result. The counter-ion $Cl^{−}$ follows passively by electrodiffusion through the paracellular pathway. Water follows by osmosis, but specific routes for water across the epithelium are unknown. Remarkably, the transepithelial secretion of NaCl, KCl and water is driven by a $H^{+}$ V-ATPase located in the apical brush border membrane of principal cells and not the canonical Na/K ATPase. A hypothetical $cation/H^{+}$ exchanger moves $Na^{+}$ and $K^{+}$ from the cytoplasm to the tubule lumen. Also remarkable is the dynamic regulation of the paracellular permeability with switch-like speed which mediates in part the post-blood-meal diuresis in mosquitoes. For example, the blood meal the female mosquito takes to nourish her eggs triggers the release of kinin diuretic peptides that 1) increases the $Cl^{−}$ conductance of the paracellular pathway, and 2) assembles $V_{1}$ and $V_{0}$ complexes to activate the $H^{+}$ V-ATPase and $cation/H^{+}$ exchange close by. Thus, transcellular and paracellular pathways are both stimulated to quickly rid the mosquito of the unwanted salts and water of the blood meal. Stellate cells of the tubule appear to serve a metabolic support role, exporting the $HCO_{3}^{−}$ generated during stimulated transport activity. Septate junctions define the properties of the paracellular pathway in Malpighian tubules, but the proteins responsible for the permselectivity and barrier functions of the septate junction are unknown.
File Format	HTM / HTML
ISSN	17481708
e-ISSN	17481716
DOI	10.1111/j.1748-1716.2010.02195.x
Journal	Acta Physiologica
Issue Number	3
Volume Number	202
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2011-07-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Physiology Aedes Anatomy & Histology Physiology Biological Transport Epithelial Cells Malpighian Tubules Adenosine Triphosphatases Metabolism Animals Cell Membrane Permeability Cell Polarity Chlorides Diuresis Intercellular Junctions Ion Channels Kinins Potassium Potassium Chloride Signal Transduction Sodium Sodium Chloride Research Support, N.i.h., Extramural Research Support, U.s. Gov't, Non-p.h.s.
Content Type	Text
Resource Type	Article
Subject	Physiology

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Transcellular and Paracellular Pathways of Transepithelial Fluid Secretion in Malpighian (renal) Tubules of the Yellow Fever Mosquito Aedes aegypti

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Transcellular and Paracellular Pathways of Transepithelial Fluid Secretion in Malpighian (renal) Tubules of the Yellow Fever Mosquito Aedes aegypti

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