NDLI: Oxygen Gradients in the Microcirculation

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Pittman, R. N.
Description	Country affiliation: United States Author Affiliation: Pittman RN ( Department of Physiology and Biophysics, Virginia Commonwealth University, Richmond, VA 23298, USA. pittman@vcu.edu)
Abstract	Early in the last century August Krogh embarked on a series of seminal studies to understand the connection between tissue metabolism and mechanisms by which the cardiovascular system supplied oxygen to meet those needs. Krogh recognized that oxygen was supplied from blood to the tissues by passive diffusion and that the most likely site for oxygen exchange was the capillary network. Studies of tissue oxygen consumption and diffusion coefficient, coupled with anatomical studies of capillarity in various tissues, led him to formulate a model of oxygen diffusion from a single capillary. Fifty years after the publication of this work, new methods were developed which allowed the direct measurement of oxygen in and around microvessels. These direct measurements have confirmed the predictions by Krogh and have led to extensions of his ideas resulting in our current understanding of oxygenation within the microcirculation. Developments during the last 40 years are reviewed, including studies of oxygen gradients in arterioles, capillaries, venules, microvessel wall and surrounding tissue. These measurements were made possible by the development and use of new methods to investigate oxygen in the microcirculation, so mention is made of oxygen microelectrodes, microspectrophotometry of haemoglobin and phosphorescence quenching microscopy. Our understanding of oxygen transport from the perspective of the microcirculation has gone from a consideration of oxygen gradients in capillaries and tissue to the realization that oxygen has the ability to diffuse from any microvessel to another location under the conditions that there exists a large enough $PO_{2}$ gradient and that the permeability for oxygen along the intervening pathway is sufficient.
File Format	HTM / HTML
ISSN	17481708
e-ISSN	17481716
DOI	10.1111/j.1748-1716.2010.02232.x
Journal	Acta Physiologica
Issue Number	3
Volume Number	202
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2011-07-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Physiology Microcirculation Physiology Oxygen Blood Animals Arterioles Anatomy & Histology Metabolism Capillaries Diffusion Hemoglobins Microscopy Muscle Contraction Muscle, Skeletal Blood Supply Oxygen Consumption Partial Pressure Sulfates Venules Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Physiology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Dynamics of Muscle Microcirculatory and Blood-myocyte $O_{2}$ Flux During Contractions

Counterpoint: There is not capillary recruitment in active skeletal muscle during exercise.

Capillary blood volume increase in already perfused capillaries: role for glycocalyx modulation.

$Po_{2}$ measurements in the microcirculation using phosphorescence quenching microscopy at high magnification

Macromolecule permeability of in situ and excised rodent skeletal muscle arterioles and venules.

Theoretical Models of Microvascular Oxygen Transport to Tissue

Inflammation-responsive focal constrictors in the mouse ear microcirculation.

Last word on Point:Counterpoint: There is/is not capillary recruitment in active skeletal muscle during exercise. (Part 1)

Last word on Point:Counterpoint: There is/is not capillary recruitment in active skeletal muscle during exercise. (Part 2)

Oxygen Gradients in the Microcirculation

Similar Documents

Dynamics of Muscle Microcirculatory and Blood-myocyte $O_{2}$ Flux During Contractions

Counterpoint: There is not capillary recruitment in active skeletal muscle during exercise.

Capillary blood volume increase in already perfused capillaries: role for glycocalyx modulation.

$Po_{2}$ measurements in the microcirculation using phosphorescence quenching microscopy at high magnification

Macromolecule permeability of in situ and excised rodent skeletal muscle arterioles and venules.

Theoretical Models of Microvascular Oxygen Transport to Tissue

Inflammation-responsive focal constrictors in the mouse ear microcirculation.

Last word on Point:Counterpoint: There is/is not capillary recruitment in active skeletal muscle during exercise. (Part 1)

Last word on Point:Counterpoint: There is/is not capillary recruitment in active skeletal muscle during exercise. (Part 2)

Oxygen Gradients in the Microcirculation