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Evaluation of the reproductive toxicity of naproxen sodium and meloxicam in male rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Uzun, B. Atli, O. Perk, B. O. Burukoglu, D. Ilgin, S.
Description	Country affiliation: Turkey Author Affiliation: Uzun B ( Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Anadolu University, Eskisehir, Turkey.); Atli O ( Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Anadolu University, Eskisehir, Turkey.); Perk BO ( Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Anadolu University, Eskisehir, Turkey.); Burukoglu D ( Department of Histology, Faculty of Medicine, Osmangazi University, Eskisehir, Turkey.); Ilgin S ( Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Anadolu University, Eskisehir, Turkey silgin@anadolu.edu.tr.)
Abstract	Nonsteroidal anti-inflammatory drugs that are cyclooxygenase (COX) enzyme inhibitors have generally been used in short-term pain management and also to treat inflammation chronically. It is known that COX enzyme and prostaglandins play important roles in the regulation of reproductive functions in females. However, there are relatively few studies for the male reproductive system, and the results of these studies are contradictory. In this study, sperm count and motility, COX-1, COX-2, prostaglandin E1 (PGE1), prostaglandin E2 (PGE2), and prostaglandin F2 (PGF2 ) levels in testis tissue, plasma follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone levels, and histopathological examination of testis tissue were evaluated after naproxen sodium and meloxicam administration in male rats. Also, testis superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), and glutathione (GSH) levels were measured to investigate the oxidation status. According to our results, sperm count and motility were significantly decreased in treatment groups. Plasma hormone levels did not show any statistical differences between the groups. COX-1, PGE2, and PGF2 levels were significantly decreased, while the decreases in COX-2 and PGE1 levels did not show any significance statistically. Testis SOD, catalase, GPx, and GSH levels were decreased significantly. According to the results of histopathological examination, damage in seminiferous tubules, where spermatogenesis developed, was observed. In conclusion, naproxen sodium and meloxicam decreased the sperm count and motility and also induced the damage of seminiferous tubules as a direct effect without affecting plasma hormone levels in our study. The mechanism of the reproductive toxicity induced by these agents may be based on the inhibition of prostaglandin synthesis and the induction of oxidative stress can be emphasized as a secondary factor.
File Format	HTM / HTML
ISSN	09603271
Issue Number	4
Volume Number	34
e-ISSN	14770903
Journal	Human & Experimental Toxicology
Language	English
Publisher	Sage Publication
Publisher Date	2015-04-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Toxicology Cyclooxygenase Inhibitors Toxicity Naproxen Testis Drug Effects Thiazines Thiazoles Alprostadil Metabolism Animals Catalase Dinoprostone Follicle Stimulating Hormone Blood Glutathione Glutathione Peroxidase Luteinizing Hormone Male Rats, Wistar Sperm Count Sperm Motility Superoxide Dismutase Pathology Testosterone Journal Article
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology

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