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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Himabindu, B. Madhu, P. Reddy, P. Sreenivasula |
| Description | Country affiliation: India Author Affiliation: Himabindu B ( Department of Zoology, Sri Venkateswara University, Tirupati 517 502, India.); Madhu P ( Department of Zoology, Sri Venkateswara University, Tirupati 517 502, India); Reddy PS ( Department of Zoology, Sri Venkateswara University, Tirupati 517 502, India. Electronic address: psreddy1955@gmail.com.) |
| Abstract | The aim of this study was to test whether diabetic rats exposed to alcohol demonstrate a higher degree of reproductive toxicity and suffer with elevated oxidative toxicity when compared with alcohol exposed control rats. Diabetes was induced by injecting single dose of streptozotocin and alcohol was administered through orogastric tube once daily for a period of 55 days. Daily sperm production, epididymal sperm count, motile, viable and HOS-tail coiled sperms, serum testosterone levels and testicular 3ß- and 17ß-hydroxysteroid dehydrogenase activity levels were significantly decreased in diabetic rats. Significant reduction in testicular and epididymal superoxide dismutase and catalase activity levels, and elevation in lipid peroxidation products were observed in diabetic rats. Similar reproductive and oxidative toxicity was observed in alcohol treated control rats. Further, alcohol exposed diabetic rats showed additional deterioration in reproductive endpoints and noteworthy elevation in oxidative toxicity suggesting that treatment with alcohol further deteriorates sexual dysfunction in STZ-induced diabetic rats. |
| File Format | HTM / HTML |
| ISSN | 08906238 |
| Volume Number | 51 |
| e-ISSN | 18731708 |
| Journal | Reproductive Toxicology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-01-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Embryology Discipline Reproductive Medicine Discipline Toxicology Diabetes Mellitus, Experimental Metabolism Ethanol Toxicity Oxidative Stress Drug Effects 17-hydroxysteroid Dehydrogenases Blood Animals Catalase Pathology Epididymis Follicle Stimulating Hormone Luteinizing Hormone Male Malondialdehyde Organ Size Rats, Wistar Spermatozoa Physiology Superoxide Dismutase Testis Testosterone Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Toxicology |
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