NDLI: Evaluation of genotoxic potential of commonly used organophosphate pesticides in peripheral blood lymphocytes of rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ojha, A. Gupta, Y. K.
Description	Country affiliation: India Author Affiliation: Ojha A ( Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India.); Gupta YK ( Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India yk.ykgupta@gmail.com.)
Abstract	Chlorpyrifos (CPF), methyl parathion (MPT), and malathion (MLT) are among the most extensively used organophosphate (OP) pesticides in India. DNA protein cross-links (DPC) and DNA strand breaks are toxic lesions associated with the mechanism(s) of toxicity of carcinogenic compounds. In the present study, we examined the hypothesis that individual and interactive genotoxic effects of CPF, MPT, and MLT are involved in the formation of DPC and DNA strand break. The DNA strand break was measured by comet assay and expressed as DNA damage index, while DPC estimation was carried out by fluorescence emission assay. The results showed that exposure of rat lymphocytes with CPF, MPT, and MLT caused significantly marked increase in DNA damage and DPC formation in time-dependent manner. MPT caused the highest damage, and these pesticides do not potentiate the toxicity of each other.
File Format	HTM / HTML
ISSN	09603271
Issue Number	4
Volume Number	34
e-ISSN	14770903
Journal	Human & Experimental Toxicology
Language	English
Publisher	Sage Publication
Publisher Date	2015-04-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Toxicology Chlorpyrifos Toxicity Insecticides Malathion Methyl Parathion Mutagens Animals Cells, Cultured Dna Damage Lymphocytes Drug Effects Metabolism Male Rats, Wistar Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology

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