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Human leukocyte antigens and genetic susceptibility to lymphoma.

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Human leukocyte antigens and genetic susceptibility to lymphoma.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	McAulay, K. A. Jarrett, R. F.
Description	Country affiliation: United kingdom Author Affiliation: McAulay KA ( MRC - University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.); Jarrett RF ( MRC - University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.)
Abstract	Familial aggregation, coupled with ethnic variation in incidence, suggests that inherited susceptibility plays a role in the development of lymphoma, and the search for genetic risk factors has highlighted the contribution of the human leukocyte antigen (HLA) complex. In a landmark study published almost 50 years ago, Hodgkin lymphoma (HL) was the first disease to be associated with HLA variation. It is now clear that Epstein-Barr virus (EBV)-positive and -negative HL are strongly associated with specific HLA polymorphisms but these differ by EBV status of the tumours. HLA class I alleles are consistently associated with EBV-positive HL while a polymorphism in HLA class II is the strongest predictor of risk of EBV-negative HL. Recent investigations, particularly genome-wide association studies (GWAS), have also revealed associations between HLA and common types of non-Hodgkin lymphoma (NHL). Follicular lymphoma is strongly associated with two distinct haplotypes in HLA class II whereas diffuse large B-cell lymphoma is most strongly associated with HLA-B*08. Although chronic lymphocytic leukaemia is associated with variation in HLA class II, the strongest signals in GWAS are from non-HLA polymorphisms, suggesting that inherited susceptibility is explained by co-inheritance of multiple low risk variants. Associations between B-cell derived lymphoma and HLA variation suggest that antigen presentation, or lack of, plays an important role in disease pathogenesis but the precise mechanisms have yet to be elucidated.
File Format	HTM / HTML
ISSN	20592302
Issue Number	2
Volume Number	86
e-ISSN	20592310
Journal	Tissue Antigens
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2015-08-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Genetics Discipline Immunology Epstein-barr Virus Infections Genetics Genetic Predisposition To Disease Histocompatibility Antigens Class Ii Histocompatibility Antigens Class I Hodgkin Disease Lymphoma, Non-hodgkin Alleles Complications Immunology Pathology Gene Expression Genome-wide Association Study Haplotypes Herpesvirus 4, Human Pathogenicity Physiology Humans Polymorphism, Single Nucleotide Journal Article Review
Content Type	Text
Resource Type	Article
Subject	Genetics Immunology and Allergy Immunology

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Human leukocyte antigens and genetic susceptibility to lymphoma.

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