NDLI: A genetic coding variant rs72474224 in GJB2 is associated with clinical features of psoriasis vulgaris in a Chinese Han population.

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A genetic coding variant rs72474224 in GJB2 is associated with clinical features of psoriasis vulgaris in a Chinese Han population.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yao, F. Yue, M. Zhang, C. Zuo, X. Zheng, X. Zhang, A. Wang, Z. Liu, S. Li, H. Meng, L. Zeng, M. Fan, X. Sun, L. Zhang, X.
Description	Country affiliation: China Author Affiliation: Yao F ( Institute of Dermatology and Department of Dermatology, Anhui Medical University, Hefei, China.); Yue M ( State Key Laboratory Incubation Base of Dermatology, Anhui Medical University, Hefei, China.); Zhang C ( Department of Dermatology at Anqing Hospital, Anhui Medical University, Hefei, China.); Zuo X ( Institute of Dermatology and Department of Dermatology, Anhui Medical University, Hefei, China.); Zheng X ( State Key Laboratory Incubation Base of Dermatology, Anhui Medical University, Hefei, China.); Zhang A ( Institute of Dermatology and Department of Dermatology, Anhui Medical University, Hefei, China.); Wang Z ( State Key Laboratory Incubation Base of Dermatology, Anhui Medical University, Hefei, China.); Liu S ( Institute of Dermatology and Department of Dermatology, Anhui Medical University, Hefei, China.); Li H ( State Key Laboratory Incubation Base of Dermatology, Anhui Medical University, Hefei, China.); Meng L ( Institute of Dermatology and Department of Dermatology, Anhui Medical University, Hefei, China.); Zeng M ( State Key Laboratory Incubation Base of Dermatology, Anhui Medical University, Hefei, China.); Fan X ( Institute of Dermatology and Department of Dermatology, Anhui Medical University, Hefei, China.); Sun L ( State Key Laboratory Incubation Base of Dermatology, Anhui Medical University, Hefei, China.); Zhang X ( Institute of Dermatology and Department of Dermatology, Anhui Medical University, Hefei, China.)
Abstract	Our recent targeted sequencing study identified a missense single-nucleotide polymorphism rs72474224 (c.324C>T) in GJB2. To investigate the correlation between rs72474224 (c.324C>T) and subphenotypes of psoriasis, genotype data for rs72474224 (c.324C>T, p.Val37Ile) was analyzed in 9946 cases and 9906 controls. The additive model provided the best fit for rs72474224 (P = 7.34 × 10(-9)). The genotypic and allelic frequency distributions were associated with plaque psoriasis in case-only (Pgenotype = 2.67 × 10(-3), Pallele = 6.22 × 10(-4)) and subphenotype-control (Pgenotype = 1.58 × 10(-11), Pallele = 8.16 × 10(-12)) analyses. No other significant difference was found in case-only analyses. Rs72474224 in GJB2 is preferentially associated with plaque psoriasis in Chinese population and might contribute to the complexity of psoriasis clinical features.
File Format	HTM / HTML
ISSN	20592302
Issue Number	2
Volume Number	86
e-ISSN	20592310
Journal	Tissue Antigens
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2015-08-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Genetics Discipline Immunology Connexins Genetics Exons Polymorphism, Single Nucleotide Psoriasis Adolescent Adult Aged Aged, 80 And Over Alleles Asian Continental Ancestry Group Case-control Studies Child Child, Preschool Immunology Female Gene Expression Gene Frequency Genetic Association Studies Genetic Predisposition To Disease Genotype Humans Infant Male Middle Aged Models, Genetic Ethnology Pathology Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Genetics Immunology and Allergy Immunology

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A genetic coding variant rs72474224 in GJB2 is associated with clinical features of psoriasis vulgaris in a Chinese Han population.

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A genetic coding variant rs72474224 in GJB2 is associated with clinical features of psoriasis vulgaris in a Chinese Han population.