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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Delahaye-Sourdeix, Manon Urayama, Kevin Y. Gaborieau, Valérie Veenstra, Rianne Foll, Matthieu Chabrier, Amelie Benavente, Yolanda Nieters, Alexandra Becker, Nikolaus Foretova, Lenka Maynadié, Marc Staines, Anthony Smedby, Karin Ekstrom Glimelius, Ingrid Lightfoot, Tracy Cocco, Pierluigi Galan, Pilar Vatten, Lars J. Duell, Eric J. Kiemeney, Lambertus Roman, Eve de Sanjosé, Silvia Lathrop, Mark Melbye, Mads Brennan, Paul Diepstra, Arjan Van Den Berg, Anke Hjalgrim, Henrik Jarrett, Ruth F. McKay, James D. |
| Spatial Coverage | Scandinavian and Nordic Countries Netherlands |
| Description | Country affiliation: France Author Affiliation: Delahaye-Sourdeix M ( International Agency for Research on Cancer (IARC), Lyon, France.); Urayama KY ( Department of Human Genetics and Disease Diversity, Tokyo Medical and Dental University, Tokyo, Japan.); Gaborieau V ( International Agency for Research on Cancer (IARC), Lyon, France.); Veenstra R ( Department of Pathology and Medical Biology, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.); Foll M ( International Agency for Research on Cancer (IARC), Lyon, France.); Chabrier A ( International Agency for Research on Cancer (IARC), Lyon, France.); Benavente Y ( Unit of Infections and Cancer, Cancer Epidemiology Research Programme, IDIBELL, Catalan Institute of Oncology, Barcelona, Spain. CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.); Nieters A ( Centre of Chronic Immunodeficiency Freiburg, University Medical Centre Freiburg, Freiburg, Germany.); Becker N ( Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.); Foretova L ( Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.); Maynadié M ( Registry of Hematological Malignancies, University of Burgundy, University Hospital of Dijon, Dijon, France.); Staines A ( School of Nursing, Dublin City University, Glasnevin, Dublin, Ireland.); Smedby KE ( Department of Medicine Solna, Clinical Epidemiology Unit, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden.); Glimelius I ( Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden. Department of Radiology, Oncology, and Clinical Immunology, Uppsala University, Uppsala, Sweden.); Lightfoot T ( Epidemiology and Genetics Unit, Department of Health Sciences, University of York, York, United Kingdom.); Cocco P ( Department of Public Health, Occupational Health Section, University of Cagliari, Cagliari, Italy.); Galan P ( Sorbonne Paris Cité Epidemiology and Biostatistics Research Center (CRESS), Nutritional Epidemiology Research Team (EREN), Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, Bobigny, France.); Vatten LJ ( Norwegian University of Science and Technology, Trondheim, Norway.); Duell EJ ( Unit of Infections and Cancer, Cancer Epidemiology Research Programme, IDIBELL, Catalan Institute of Oncology, Barcelona, Spain.); Kiemeney L ( Radboud University Medical Centre, Radboud Institute for Health Sciences, Nijmegen, the Netherlands.); Roman E ( Epidemiology and Genetics Unit, Department of Health Sciences, University of York, York, United Kingdom.); de Sanjosé S ( Unit of Infections and Cancer, Cancer Epidemiology Research Programme, IDIBELL, Catalan Institute of Oncology, Barcelona, Spain. CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.); Lathrop M ( McGill University and Genome Quebec Innovation Centre, Montreal, Quebec, Canada.); Melbye M ( Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.); Brennan P ( International Agency for Research on Cancer (IARC), Lyon, France.); Diepstra A ( Department of Pathology and Medical Biology, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.); van den Berg A ( Department of Pathology and Medical Biology, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.); Hjalgrim H ( Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.); Jarrett RF ( MRC University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow, United Kingdom.); McKay JD ( International Agency for Research on Cancer (IARC), Lyon, France. gcs@iarc.fr.) |
| Abstract | BACKGROUND: A proportion of the genetic variants involved in susceptibility to Hodgkin lymphoma differ by the tumor's Epstein-Barr virus (EBV) status, particularly within the MHC region. METHODS: We have conducted an SNP imputation study of the MHC region, considering tumor EBV status in 1,200 classical Hodgkin lymphoma (cHL) cases and 5,726 control subjects of European origin. Notable findings were genotyped in an independent study population of 468 cHL cases and 551 controls. RESULTS: We identified and subsequently replicated a novel association between a common genetic variant rs6457715 and cHL. Although strongly associated with EBV-positive cHL [OR, 2.33; 95% confidence interval (CI), 1.83-2.97; P = 7 × 10(-12)], there was little evidence for association between rs6457715 and the EBV-negative subgroup of cHL (OR, 1.06; 95% CI, 0.92-1.21), indicating that this association was specific to the EBV-positive subgroup (Phet < P = 10(-8)). Furthermore, the association was limited to EBV-positive cHL subgroups within mixed cell (MCHL) and nodular sclerosis subtypes (NSHL), suggesting that the association is independent of histologic subtype of cHL. CONCLUSIONS: rs6457715, located near the HLA-DPB1 gene, is associated with EBV-positive cHL and suggests this region as a novel susceptibility locus for cHL. IMPACT: This expands the number of genetic variants that are associated with cHL and provides additional evidence for a critical and specific role of EBV in the etiology of this disease. |
| File Format | HTM / HTML |
| ISSN | 10559965 |
| e-ISSN | 15387755 |
| Journal | Cancer Epidemiology Biomarkers & Prevention |
| Issue Number | 12 |
| Volume Number | 24 |
| Language | English |
| Publisher | American Association for Cancer Research |
| Publisher Date | 2015-12-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Cancer epidemiology Chromosomes, Human, Pair 6 Epstein-barr Virus Infections Genetics Hodgkin Disease Virology Adolescent Case-control Studies Epidemiology Pathology Genetic Predisposition To Disease Major Histocompatibility Complex Netherlands Polymorphism, Single Nucleotide Scandinavian And Nordic Countries Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Epidemiology Oncology |
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