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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Becker, Nikolaus Zhang, Yawei Vineis, Paolo Spinelli, John J. de Sanjose, Silvia Foo, Jia-Nee Birmann, Brenda M. Bertrand, Kimberly A. Vijai, Joseph Wang, Sophia S. Salles, Gilles Lan, Qing Lightfoot, Tracy Albanes, Demetrius Zeleniuch-Jacquotte, Anne Huang, Jinyan Vermeulen, Roel C. H. Bracci, Paige M. Liang, Liming Purdue, Mark P. Ghesquières, Hervé Yeager, Meredith Link, Brian K. Ma, Baoshan Linet, Martha S. Wang, Zhaoming Teras, Lauren R. Gabbas, Attilio Lawrence, Charles Berndt, Sonja I. Giles, Graham G. Chung, Charles C. Burdett, Laurie Vajdic, Claire M. Hjalgrim, Henrik Smith, Alex Monnereau, Alain Hutchinson, Amy Morton, Lindsay M. Slager, Susan L. Conde, Lucia Severi, Gianluca Melbye, Mads Gu, Jian Kricker, Anne Tinker, Lesley F. Skibola, Christine F. Montalvan, Rebecca de Bakker, Paul I. W. Holly, Elizabeth A. |
| Description | Author Affiliation: Skibola CF ( Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, Birmingham, AL 35233, USA); Berndt SI ( Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.); Vijai J ( Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.); Conde L ( Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, Birmingham, AL 35233, USA); Wang Z ( Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Gaithersburg, MD 20877, USA.); Yeager M ( Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Gaithersburg, MD 20877, USA.); de Bakker PI ( Department of Medical Genetics and of Epidemiology, University Medical Center Utrecht, Utrecht 3584 CG, the Netherlands); Birmann BM ( Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.); Vajdic CM ( Prince of Wales Clinical School, University of New South Wales, Sydney, NSW 2052, Australia.); Foo JN ( Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore.); Bracci PM ( Department of Epidemiology & Biostatistics, University of California, San Francisco, San Francisco, CA 94118, USA.); Vermeulen RC ( Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht 3584 CX, the Netherlands); Slager SL ( Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA.); de Sanjose S ( Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d'Oncologia, IDIBELL, Barcelona 8907, Spain); Wang SS ( Department of Cancer Etiology, City of Hope Beckman Research Institute, Duarte, CA 91030, USA.); Linet MS ( Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.); Salles G ( Department of Hematology, Hospices Civils de Lyon, Pierre benite Cedex 69495, France); Lan Q ( Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.); Severi G ( Human Genetics Foundation, Turin 10126, Italy); Hjalgrim H ( Department of Epidemiology Research, Division of Health Surveillance and Research, Statens Serum Institut, Copenhagen 2300, Denmark.); Lightfoot T ( Department of Health Sciences, University of York, York YO10 5DD, UK.); Melbye M ( Department of Epidemiology Research, Division of Health Surveillance and Research, Statens Serum Institut, Copenhagen 2300, Denmark); Gu J ( Department of Epidemiology, M.D. Anderson Cancer Center, Houston, TX 77030, USA.); Ghesquières H ( Laboratoire de Biologie Moléculaire de la Cellule UMR 5239, Centre National de la Recherche Scientifique, Pierre benite Cedex 69495, France); Link BK ( Department of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA.); Morton LM ( Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.); Holly EA ( Department of Epidemiology & Biostatistics, University of California, San Francisco, San Francisco, CA 94118, USA.); Smith A ( Department of Health Sciences, University of York, York YO10 5DD, UK.); Tinker LF ( Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98117, USA.); Teras LR ( Epidemiology Research Program, American Cancer Society, Atlanta, GA 30303, USA.); Kricker A ( Sydney School of Public Health, The University of Sydney, Sydney, NSW 2006, Australia.); Becker N ( Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Baden-Württemberg 69120, Germany.); Purdue MP ( Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.); Spinelli JJ ( Cancer Control Research, BC Cancer Agency, Vancouver, BC V5Z 1L3, Canada); Zhang Y ( Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT 06520, USA.); Giles GG ( Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC 3053, Australia); Vineis P ( Human Genetics Foundation, Turin 10126, Italy); Monnereau A ( Environmental Epidemiology of Cancer Group, Inserm, Centre for Research in Epidemiology and Population Health (CESP), U1018, Villejuif Cedex 94807, France); Bertrand KA ( Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA); Albanes D ( Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.); Zeleniuch-Jacquotte A ( Department of Population Health, New York University School of Medicine, New York, NY 10016, USA); Gabbas A ( Department of Public Health, Clinical and Molecular Medicine, University of Cagliari, Monserrato, Cagliari 09042, Italy.); Chung CC ( Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.); Burdett L ( Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Gaithersburg, MD 20877, USA.); Hutchinson A ( Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Gaithersburg, MD 20877, USA.); Lawrence C ( Health Studies Sector, Westat, Rockville, MD 20850, USA.); Montalvan R ( Health Studies Sector, Westat, Rockville, MD 20850, USA.); Liang L ( Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA); Huang J ( Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.); Ma B ( Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA) |
| Abstract | Genome-wide association studies (GWASs) of follicular lymphoma (FL) have previously identified human leukocyte antigen (HLA) gene variants. To identify additional FL susceptibility loci, we conducted a large-scale two-stage GWAS in 4,523 case subjects and 13,344 control subjects of European ancestry. Five non-HLA loci were associated with FL risk: 11q23.3 (rs4938573, p = 5.79 × 10(-20)) near CXCR5; 11q24.3 (rs4937362, p = 6.76 × 10(-11)) near ETS1; 3q28 (rs6444305, p = 1.10 × 10(-10)) in LPP; 18q21.33 (rs17749561, p = 8.28 × 10(-10)) near BCL2; and 8q24.21 (rs13254990, p = 1.06 × 10(-8)) near PVT1. In an analysis of the HLA region, we identified four linked HLA-DRß1 multiallelic amino acids at positions 11, 13, 28, and 30 that were associated with FL risk (pomnibus = 4.20 × 10(-67) to 2.67 × 10(-70)). Additional independent signals included rs17203612 in HLA class II (odds ratio [OR(per-allele)] = 1.44; p = 4.59 × 10(-16)) and rs3130437 in HLA class I (OR(per-allele) = 1.23; p = 8.23 × 10(-9)). Our findings further expand the number of loci associated with FL and provide evidence that multiple common variants outside the HLA region make a significant contribution to FL risk. |
| ISSN | 00029297 |
| e-ISSN | 15376605 |
| DOI | 10.1016/j.ajhg.2014.09.004 |
| Journal | The American Journal of Human Genetics |
| Issue Number | 4 |
| Volume Number | 95 |
| Language | English |
| Publisher | Cell Press (on behalf of American Society of Human Genetics) |
| Publisher Date | 2014-10-02 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Tumor Markers, Biological Genetics Chromosomes, Human Genetic Predisposition To Disease Genome-wide Association Study Hla Antigens Lymphoma, Follicular Polymorphism, Single Nucleotide Alleles Case-control Studies Haplotypes Comparative Study Research Support, N.i.h., Intramural Discipline Human Genetics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Genetics (clinical) |
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