NDLI: Inflammatory bowel disease: susceptibility and disease heterogeneity revealed by human leukocyte antigen genotyping.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bouzid, Dorra Kammoun, Arwa Amouri, Ali Mahfoudh, Nadia Haddouk, Samy Tahri, Nabil Makni, Hafedh Masmoudi, Hatem
Spatial Coverage	Tunisia
Description	Country affiliation: Tunisia Author Affiliation: Bouzid D ( Immunology Department, Habib Bourguiba Hospital, Sfax, Tunisia. dorra-ing@voila.fr)
Abstract	This study aimed to investigate the association between HLA DR/DQ and inflammatory bowel diseases (IBD) in Tunisian patients and to determine the relationship between HLA DR/DQ alleles with the clinical disease patterns. DNA typing of human leukocyte antigen (HLA) genes was performed in 70 ulcerative colitis (UC) patients, 40 Crohn's disease (CD) patients, and 123 healthy controls (HC) using a polymerase chain reaction sequence specific primer technique. Data were analyzed using Cochran-Mantel-Haenszel test and binary logistic regression. Compared with HC, IBD patients showed an increased frequency of the homozygous DRB107 genotype. This positive association was maintained when UC and CD were separately compared to HC. In UC patients, DQB103:02 was predictive of colonic extension whereas DRB113 and DQB103:01 were associated limited disease localization (left-sided colitis and proctitis). The DRB115 allele increased in patients with extraintestinal manifestations. In CD, female patients showed an increased frequency of DRB113, DRB115, and DQB106 alleles and DRB113-DQB106 haplotype, whereas a significant increase of DRB107, DQB102 alleles, and DRB107-DQB102 haplotype was noted in male patients. These results show a significant association of the homozygous HLA-DRB1*07 genotype with UC and CD and of several HLA DR/DQ alleles and haplotypes with the clinical phenotypes of these diseases in Tunisian patients. Because of limited statistical power, our study findings are subject to further investigation.
File Format	HTM / HTML
ISSN	19450265
Issue Number	6
Volume Number	16
e-ISSN	19450257
Journal	Genetic Testing and Molecular Biomarkers
Language	English
Publisher	Mary Ann Liebert
Publisher Date	2012-06-01
Publisher Place	United States
Access Restriction	Subscribed
Subject Keyword	Discipline Genetics Discipline Molecular Biology Colitis, Ulcerative Genetics Crohn Disease Genetic Predisposition To Disease Hla-dq Antigens Hla-dr Antigens Histocompatibility Testing Inflammatory Bowel Diseases Physiopathology Adult Alleles Immunology Female Gene Frequency Genotype Hla-drb1 Chains Haplotypes Histocompatibility Antigens Class Ii Humans Male Phenotype Tunisia Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Genetics (clinical)

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