NDLI: Renewal of sucrose-seeking behavior in rats: Role of D(2) dopamine receptors.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Rauhut, Anthony S. Fenton, Laura Bardo, Michael T.
Description	Country affiliation: United States Author Affiliation: Rauhut AS ( Department of Psychology, James Hall, Dickinson College, Carlisle, PA 17013, USA. rauhuta@dickinson.edu)
Abstract	The present study characterized renewal of sucrose-seeking behavior in rats (Experiment 1). The role of the dopamine subtype-2 (D(2)) receptors in mediating renewal of sucrose-seeking behavior also was examined (Experiment 2). Rats were trained to respond for sucrose pellets (45mg each) on a fixed-ratio 25 (Experiments 1 and 2) schedule of reinforcement in Context A. Following acquisition, rats underwent extinction and 4 renewal tests in Contexts B and A, respectively. In Experiment 2, rats were pretreated with vehicle or the D(2) dopamine receptor antagonist eticlopride (5, 10, 20, or 40microg/kg) 30min prior to the first renewal test session. A follow-up experiment (Experiment 3) examined the effect of a high eticlopride dose (40microg/kg) on locomotor activity. Renewal of sucrose-seeking behavior persisted for 3 sessions. Eticlopride dose-dependently blocked renewal of sucrose-seeking behavior without suppressing locomotor activity, implicating a role of D(2) dopamine receptors in mediating renewal of sucrose-seeking behavior.
File Format	HTM / HTML
ISSN	00913057
e-ISSN	18735177
DOI	10.1016/j.pbb.2010.06.006
Journal	Pharmacology Biochemistry and Behavior
Issue Number	3
Volume Number	96
Language	English
Publisher	Elsevier
Publisher Date	2010-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Behavioral Sciences Discipline Biochemistry Discipline Pharmacology Conditioning, Operant Drug Effects Feeding Behavior Receptors, Dopamine D2 Animals Discrimination (psychology) Dopamine Antagonists Pharmacology Dose-response Relationship, Drug Extinction, Psychological Injections, Subcutaneous Motor Activity Psychomotor Performance Rats, Sprague-dawley Receptors, Dopamine D1 Reinforcement Schedule Salicylamides Sucrose Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Biological Psychiatry Behavioral Neuroscience Biochemistry Clinical Biochemistry Toxicology Pharmacology

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Renewal of Sucrose-Seeking Behavior in Rats: Role of D2 Dopamine Receptors

Renewal of sucrose-seeking behavior in rats: Role of D(2) dopamine receptors.

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