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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | McLaughlin, P. J. Winston, K. M. Swezey, L. A. Vemuri, V. K. Makriyannis, A. Salamone, J. D. |
| Description | Country affiliation: United States Author Affiliation: McLaughlin PJ ( Department of Psychology, University of Connecticut, Storrs, CT 06269-1020, USA. pmclaughlin@edinboro.edu) |
| Abstract | Overt similarities exist between the effects of systemic cannabinoid CB1 inverse agonists and dopamine (DA) antagonists on appetitive behavior. The present set of studies was undertaken to apply a fine-grained analysis of food-reinforced operant lever pressing in rats in order to compare the pattern of effects produced by administration of the CB1 inverse agonist AM 251 and those induced by the DA D1 antagonist SKF 83566, and the D2 antagonist raclopride. Three groups of rats were trained on a fixed-ratio 5 (FR5) schedule and administered these compounds over a range of doses expected to suppress responding. All three drugs produced a dose-related suppression of total lever pressing. In addition to main effects of dose, regression analyses were performed to determine which of several response timing- and rate-related variables correlated most strongly with overall responding in each group. It was found that total session time spent pausing from responding was significantly better at predicting responding in the AM 251 group, while both DA antagonists produced significantly stronger regression coefficients (versus AM 251) from fast responding measures. These results suggest that, while several similarities exist, CB1, D1, and D2 antagonists are not identical in their pattern of suppression of food-maintained lever pressing. |
| File Format | HTM / HTML |
| ISSN | 00913057 |
| Issue Number | 1 |
| Volume Number | 96 |
| e-ISSN | 18735177 |
| Journal | Pharmacology Biochemistry and Behavior |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-07-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Behavioral Sciences Discipline Biochemistry Discipline Pharmacology Conditioning, Operant Drug Effects Dopamine D2 Receptor Antagonists Drug Inverse Agonism Feeding Behavior Receptor, Cannabinoid, Cb1 Agonists Receptors, Dopamine D1 Antagonists & Inhibitors Animals Cannabinoids Pharmacology Physiology Dopamine Antagonists Dose-response Relationship, Drug Food Male Rats Rats, Sprague-dawley Receptors, Dopamine D2 Reinforcement Schedule Comparative Study Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biological Psychiatry Behavioral Neuroscience Biochemistry Clinical Biochemistry Toxicology Pharmacology |
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